Atractyloside A
Atractyloside is a toxic compound from wedelia glauca. It acts as inhibitor of oxidative phosphorylation by a specific interference with energy-transfer reactions, the effect is due to inhibition of the ADP utilizing process in the coupling system. Atractyloside, has been proposed for the antibiotic oligomycin, is an inhibitor of the energy-transfer reactions in animal mitochondria; it inhibits the phosphate uptake and the respiratory stimulation induced by P1-acceptor, but it does not interfere with the so-called resting respiration.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Chinese journal of pharmaceutical analysis, 2014.
Determination of atractyloside A in raw and bran fried rhizome of Atractylodes lancea by HPLC-ELSD.[Reference:
WebLink]
To establish a method for determination of the content of Atractyloside A in rhizome of Atractylodes lancea and compare the content of Atractyloside A in raw and bran fried rhizome of Atractylodes lancea.
METHODS AND RESULTS:
:The HPLCESLD was carried out on an analytical C18column( Agilent TCC18,4.6 mm ×250 mm,5μm) at a column temperature of 30 ℃ and a flow rate of 1. 0 mL·min1. The mobile phase was gradient elution( 010 min,2% A→8% A; 1015 min,8% A→15% A; after 15 min,15% A) with mixture liquid of acetonitrile( A)and water( B). The drift tube temperature for the ELSD was set at 50 ℃ with the nebulizing gas( nitrogen) pressure of 3. 0 × 105 Pa. The calibration curve of Atractyloside A was linear in the ranges of 0. 23904. 7800 μg( r =0.9998). The average recovery of the method for Atractyloside A was97.84%with RSD1.0%. The sample determination result was 0. 0474%0. 0852%.
CONCLUSIONS:
After the methodology validation,this method can provide the experimental basis for the quality control of rhizome of Atractylodes lancea.
