Acetylisoeugenol
Acetylisoeugenol is a mild sensitizer in vivo, it shows good antifungal activities against R. solani and F. oxysporum.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Structure-activity relationships of cinnamaldehyde and eugenol derivatives against plant pathogenic fungi.[Reference:
WebLink]
METHODS AND RESULTS:
Cinnamon bark oil showed a lower activity than clove bud oil. The fungicidal activity of cinnamaldehyde (IC50 = 75.4 and 156.9 μg/mL, respectively) and eugenol (IC50 = 58.9 and 52.9 μg/mL, respectively) against R. solani and F. oxysporum was also evalutated. Comparisons of the antifungal activities of cinnamaldehyde and eugenol derivatives revealed that α-methylcinnamaldehyde, α-methylcinnamic acid, methyleugenol, acetyleugenol, isoeugenol, methylisoeugenol, and Acetylisoeugenol showed good antifungal activities against R. solani and F. oxysporum. In structure-activity relationships, the fungicidal activity of cinnamaldehyde derivatives could be related to conjugated double bond and the length of CH chain outside the ring. In addition, the presence of the lipophilicity may have a considerable influence on the toxicity of phenylpropenes.
CONCLUSIONS:
The present approach may help future work in the search for fungicidal compounds.
J Dermatol. 1985 Apr;12(2):153-60.
Factors influencing conjugation of phenolic compounds with the epsilon-amino group.[Reference:
WebLink]
METHODS AND RESULTS:
Factors influencing the conjugation potency of eugenol (E), isoeugenol (IE), methyl isoeugenol (MIE), and Acetylisoeugenol (AIE) with [l-14C]07-aminocaproic acid are investigated. The conjugation reaction for IE is accelerated in the presence of H2O2-peroxidase and inhibited under anaerobic conditions by nitrogen gas flow. An oxidation reaction is found to be necessary for the conjugation of IE with 07-aminocaproic acid. Immediately after mixing the phenolic compounds with [1-14C]07-aminocaproic acid and H2O2-peroxidase, the main conjugates are 7.7% for IE, 2.1% for E, 0.7% for AIE, and 0.2% for MIE. IE, which is a potent sensitizer in vivo, produces the greatest amount of conjugates while MIE, which is negative in vivo, produces almost no conjugates.
CONCLUSIONS:
AIE and E, both mild sensitizers in vivo, produce less conjugates than IE.
