Aburatubolactam A
Aburatubolactam A is an inhibitor of superoxide anion generation. It has demonstrated cytotoxic activity against P388 murine leukemia cell lines (IC50 = 26 ug/mL) and inhibits TPA-induced superoxide anion generation by human neutrophils; enhanced levels of superoxide anion is thought to be closely related to inflammation, cancer, and aging.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Dissertations & Theses - Gradworks, 2008,3308674.
Synthesis of marine natural products: Aburatubolactam A and the halichondrins.[Reference:
WebLink]
Aburatubolactam A is a tetramic acid macrolactam isolated by Uemura and coworkers in 1996 from the cultured broth of a sp., SCRC-A20, taken from the surface of a mollusk collected on the seashore near Aburatubo, Kanagawa Prefecture, Japan.
METHODS AND RESULTS:
Aburatubolactam A has demonstrated cytotoxic activity against P388 murine leukemia cell lines (IC= 26 ug/mL) and inhibits TPA-induced superoxide anion generation by human neutrophils. Enhanced levels of superoxide anion is thought to be closely related to inflammation, cancer, and aging. Unfortunately, inadequate quantities of material were isolated to allow broader testing.
Heterocyclic Communications, 1996, 2(4):315-8.
Aburatubolactam A, a novel inhibitor of superoxide anion generation from a marine microorganism.[Reference:
WebLink]
Aburatubolactam A (1), isolated from the cultured broth of a Streptomyces sp., SCRC-A20, separated from a mollusk, potently inhibited superoxide anion generation. The structure of Aburatubolactam A was determined by X-ray crystallographic analysis and the complete assignment of the resonances in the 1H-NMR spectrum was achieved.
