8alpha-Hydroxyhirsutinolide

8alpha-Hydroxyhirsutinolide
Product Name 8alpha-Hydroxyhirsutinolide
CAS No.: 1394156-45-6
Catalog No.: CFN96809
Molecular Formula: C15H20O6
Molecular Weight: 296.31 g/mol
Purity: >=98%
Type of Compound: Sesquiterpenoids
Physical Desc.: Powder
Targets: NO | TNF-α | NF-kB
Source: The flowers of Vernonia cinerea.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
8alpha-Hydroxyhirsutinolide shows anti-inflammatory activity, it inhibits TNF-α-induced NF-κB activity with the IC(50) value of 1.9 uM.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • J Sep Sci.2022, 45(18):3556-3566.
  • Sains Malaysiana2024, 53(2):397-408.
  • Food Bioscience2023, 59:103903
  • Journal of Applied Biology & Biotechnology2023,11(4):148-158
  • bioRxiv - Biochemistry2023, 541790.
  • Spectrochim Acta A2019, 210:372-380
  • Molecules.2023, 28(3):958.
  • Int J Mol Sci.2021, 22(21):11447.
  • RSC Adv.2018, 32621-32636
  • Thorac Cancer.2023, 14(21):2007-2017.
  • Piptocarphin F

    Catalog No: CFN89128
    CAS No: 76215-53-7
    Price: Inquiry(manager@chemfaces.com)
    1-O-Ethylpiptocarphin F

    Catalog No: CFN89114
    CAS No: 142891-12-1
    Price: Inquiry(manager@chemfaces.com)
    3-O-Methyltagitinin F

    Catalog No: CFN99204
    CAS No: 110382-37-1
    Price: Inquiry(manager@chemfaces.com)
    Tirotundin

    Catalog No: CFN98943
    CAS No: 56377-67-4
    Price: Inquiry(manager@chemfaces.com)
    3-O-Methyltirotundin

    Catalog No: CFN99038
    CAS No: 1021945-29-8
    Price: Inquiry(manager@chemfaces.com)
    Tagitinin A

    Catalog No: CFN97012
    CAS No: 59979-61-2
    Price: Inquiry(manager@chemfaces.com)
    1-Acetyltagitinin A

    Catalog No: CFN97030
    CAS No: 60547-63-9
    Price: Inquiry(manager@chemfaces.com)
    8alpha-Hydroxyhirsutinolide

    Catalog No: CFN96809
    CAS No: 1394156-45-6
    Price: Inquiry(manager@chemfaces.com)
    8alpha-(2-Methylacryloyloxy)hirsutinolide

    Catalog No: CFN96807
    CAS No: 188293-70-1
    Price: Inquiry(manager@chemfaces.com)
    8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate

    Catalog No: CFN96805
    CAS No: 67667-71-4
    Price: Inquiry(manager@chemfaces.com)
    Bioorg Med Chem Lett. 2012 Sep 1;22(17):5559-62.
    Anti-inflammatory sesquiterpene lactones from the flower of Vernonia cinerea.[Pubmed: 22850207 ]

    METHODS AND RESULTS:
    Bioassay-guided fractionation of the hexane extract from the flowers of Vernonia cinerea (Asteraceae) led to the isolation of a new sesquiterpene lactone, 8alpha-Hydroxyhirsutinolide (2), and a new naturally occurring derivative, 8α-hydroxyl-1-O-methylhirsutinolide (3), along with seven known compounds (1 and 4-9). The structures of the new compounds were determined by 1D and 2D NMR experiments and by comparison with the structure of compound 1, whose relative stereochemistry was determined by X-ray analysis. The isolated compounds were evaluated for their cancer chemopreventive potential based on their ability to inhibit nitric oxide (NO) production and tumor necrosis factor alpha (TNF-α)-induced NF-κB activity.
    CONCLUSIONS:
    Compounds 1, 2, 4, 5, and 9 inhibited TNF-α-induced NF-κB activity with IC(50) values of 3.1, 1.9, 0.6, 5.2, and 1.6 μM, respectively; compounds 4 and 6-9 exhibited significant NO inhibitory activity with IC(50) values of 2.0, 1.5, 1.2, 2.7, and 2.4 μM, respectively.
    Obovatol

    Catalog No: CFN95054
    CAS No: 83864-78-2
    Price: $318/5mg
    Quercetin 3-Caffeylrobinobioside

    Catalog No: CFN95151
    CAS No: 957110-26-8
    Price: $413/5mg
    (R)-O-isobutyroyllomatin

    Catalog No: CFN95250
    CAS No: 440094-38-2
    Price: $318/5mg
    Quercetin 3-O-beta-D-glucosyl-(1->2)-rhamnoside

    Catalog No: CFN95277
    CAS No: 143016-74-4
    Price: $238/20mg
    Methylpicraquassioside B

    Catalog No: CFN95379
    CAS No: 1443757-89-8
    Price: $318/10mg
    Caffeic acid 4-O-glucuronide

    Catalog No: CFN95382
    CAS No: 1093679-71-0
    Price: Inquiry(manager@chemfaces.com)
    Platycodin J

    Catalog No: CFN95395
    CAS No: 1325614-80-9
    Price: $318/5mg
    Dihydroconfertin

    Catalog No: CFN95523
    CAS No: 68832-40-6
    Price: $318/5mg
    Ephedrannin A

    Catalog No: CFN95579
    CAS No: 82001-39-6
    Price: $318/5mg
    N-Methyldehydrococlaurine

    Catalog No: CFN95588
    CAS No: N/A
    Price: $318/5mg