Decuroside I
Decuroside I shows weak inhibiting activity against the primary and secondary wave aggregation of human platelet.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Tokyo Pharmaceutical University2020, 500001431953.
Front Nutr.2023, 10:1181135.
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Chem Pharm Bull (Tokyo).2017, 65(9):826-832
J Chromatogr Sci.2015, 53(5):824-9
J Cell Mol Med.2023, 27(11):1592-1602.
Metabolites2022, 12(6),507.
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Planta Med.,1986, 52(02):135-8.
Studies on coumarins of a Chinese drug [Pubmed:
3725933]
METHODS AND RESULTS:
Three kinds of new coumarin-glycosides, Decuroside I ( 1), Decuroside II ( 2), Decuroside III ( 3), which were isolated from the N-butanol extracts of the crude drug Zi-Hua Qian-Hu, the root of PEUCEDANUM DECURSIVUM Maxim. (Umbelliferae), were elucidated to be nodakenetin-4′- O-β-gentiobiose, nodakenetin-4′- Oβ-isomaltose and nodakenetin-4′- O-β-maltose, respectively, by the methods of chemical and spectral analysis. These three new compounds as well as Decuroside IV ( 4), decuroside V ( 5) and nodakenin ( 6) which were also isolated from Zi-Hua Qian-Hu were tested on human platelet aggregation induced by 2 μM ADP.
CONCLUSIONS:
Among these coumarin-glycosides, 3 and 4, showed the strongest inhibiting activity against the primary and secondary wave aggregation of human platelet. 1 and 2 had a less inhibiting effect or none at all, and 5 was rather promotive against the primary wave aggregation.
