Piptocarphin F

Piptocarphin F
Product Name Piptocarphin F
CAS No.: 76215-53-7
Catalog No.: CFN89128
Molecular Formula: C21H28O8
Molecular Weight: 408.44 g/mol
Purity: >=98%
Type of Compound: Sesquiterpenoids
Physical Desc.: Powder
Source: The aerial parts of Vernonia bockiana.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Piptocarphin F shows strong cytotoxic activities against mouse lymphoid tumor cell line P388. It also shows cytotoxic activity (IC50 3.87–12.5 umol·L−1) against the human leukemic cell line HL-60.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Cytotoxic sesquiterpene lactones from Vernonia bockiana.[Reference: WebLink]
    To investigate antitumor compounds from Vernonia bockiana.
    METHODS AND RESULTS:
    The compounds were isolated by column chromatography and preparative HPLC. Their structures were elucidated by 1H and 13C NMR spectroscopic methods and MS experiments. The antitumor activity was evaluated by testing their cytotoxicity against the human promyelomonocyte leukemic cell line HL-60 by the MTT method. Six sesquiterpene lactones, 8α-(4-hydroxymethacryloyloxy)-10α-hydroxy-13-methoxyhirsutinolide (1), 8α-methacryloyloxy-10α-hydroxy-13-O-methylhirsutinolide (2), piptocarphin A (3), 8α-[4-hydroxymethacryloyloxy]-10α-hydroxyhisutinolide-13-O-acetate (4), Piptocarphin F (5), and 8α-acetoxy-10α-hydroxy-13-O-methylhirsutinolide (6), and one known inone glycoside, saussureosides B (7), were isolated from the whole plant of V. bockiana. The six sesquiterpene lactones showed cytotoxic activity (IC50 3.87–12.5 μmol·L−1) against the human leukemic cell line HL-60 while the inone glycoside 7 was inactive in the test.
    CONCLUSIONS:
    Compounds 1, 2, 6, and 7 were obtained for the first time from this plant; The sesquiterpene lactones present in V. bockiana were active as antitumor agents against the human leukemic cell line HL-60.
    J Asian Nat Prod Res. 2008 May-Jun;10(5-6):571-5
    Cytotoxic sesquiterpenoids from Vernonia bockiana.[Pubmed: 18470811 ]

    METHODS AND RESULTS:
    Two new sesquiterpenoids, vernobockolides A (1) and B (2), along with five known ones, piptocarphin C (3), Piptocarphin F (4), piptocarphin A (5), hirsutolide (6), and beta-d-glucopyranosyl taraxinic ester (7), were isolated from the aerial part of Vernonia bockiana. Their structures were determined by spectroscopic analysis, especially 2D NMR.
    CONCLUSIONS:
    Among them, compounds 2-6 showed strong cytotoxic activities against mouse lymphoid tumor cell line P388 with the IC(50) values of 1.81, 1.32, 0.77, and 0.73 microM, respectively.
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