7beta-Methoxyrosmanol
7beta-Methoxyrosmanol inhibited acyl CoA:diacylglycerol acyltransferase (DGAT)1 activity, with the IC50 values ranging from 39.5 ± 0.6 to 144.2 ± 3.1 μM.
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
bioRxiv - Biochemistry2023, 541790.
Institute of Food Science & Technology2021, 45(9).
Microchemical Journal2023. 191:108938
Foods.2022, 11(12):1773.
Molecules.2017, 22(3)
Plants (Basel).2021, 10(6):1119.
VNU Journal of Science2023, 39(2):24-33.
Tumour Biol.2015, 36(12):9385-93
Molecules.2021, 26(2):E255.
Sci Rep.2019, 9(1):4342
Related and Featured Products
Food Chemistry, 2012, 132(4):1775-1780.
Abietane diterpenoids of Rosmarinus officinalis and their diacylglycerol acyltransferase-inhibitory activity.[Reference:
WebLink]
Inhibition of acyl CoA:diacylglycerol acyltransferase (DGAT) has been proposed as one of the drug targets for treating obesity and type 2 diabetes.
METHODS AND RESULTS:
Bioassay-guided fractionation of the MeOH-soluble extract of Rosmarinus officinalis yielded two new diacylglycerol acyltransferase (DGAT) inhibitory-abietane diterpenoids, 7β-hydroxy-20-deoxo-rosmaquinone (1) and 7β-methoxy-20-deoxo-rosmanol (2), along with six known components, carnosol (3), 7α-methoxyrosmanol (4),
7beta-Methoxyrosmanol (5), 12-methoxy-canosic acid (6), rosmanol (7), and rosmadial (8).
CONCLUSIONS:
Compounds 1–8 inhibited DGAT1 activity, with the IC50 values ranging from 39.5 ± 0.6 to 144.2 ± 3.1 μM. In particular, carnosol (3), which is one of the major compounds of MeOH-soluble extract of R. officinalis exhibits inhibition of de novo intracellular triacylglycerol synthesis in human hepatocyte HepG2 cells.
Glucoliquiritin
Catalog No: CFN95011
CAS No: 93446-18-5
Price: $318/10mg
Obovatol
Catalog No: CFN95054
CAS No: 83864-78-2
Price: $318/5mg
Rhamnocitrin 3-glucoside
Catalog No: CFN95134
CAS No: 41545-37-3
Price: $318/10mg
Dichotomine B
Catalog No: CFN95193
CAS No: 755036-41-0
Price: $318/5mg
19-O-beta-D-carboxyglucopyranosyl-12-O-beta-D-glucopyranosyl-11,16-dihydroxyabieta-8,11,13-triene
Catalog No: CFN95217
CAS No: 1011714-20-7
Price: $318/5mg
Hydroxytyrosol 1-O-glucoside
Catalog No: CFN95367
CAS No: 76873-99-9
Price: $318/10mg
Theaflavanoside II
Catalog No: CFN95380
CAS No: 943785-09-9
Price: $318/5mg
5,6,7,3',4'-Pentamethoxyflavanone
Catalog No: CFN95394
CAS No: 104193-93-3
Price: $318/5mg
Meliotocarpan D
Catalog No: CFN95401
CAS No: 83013-81-4
Price: $413/5mg
12beta-Acetoxy-3,7,11,15,23-pentaoxo-lanost-8,20-dien-26-oic acid
Catalog No: CFN95505
CAS No: 1309931-91-6
Price: $318/5mg
