7beta-Methoxyrosmanol
7beta-Methoxyrosmanol inhibited acyl CoA:diacylglycerol acyltransferase (DGAT)1 activity, with the IC50 values ranging from 39.5 ± 0.6 to 144.2 ± 3.1 μM.
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Scientific World Journal.2014, 2014:654193
The Japan Society for Analytical Chemistry2018, 67(4):201-206
Antioxidants.2022, 11(3):592.
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Molecules.2023, 28(8):3503.
Environ Toxicol.2024, tox.24246
Journal of Functional Foods2019, 52:430-441
Int J Mol Sci.2020, 21(7):2530.
Dermatologica Sinica2024, 42(1):p19-30.
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Food Chemistry, 2012, 132(4):1775-1780.
Abietane diterpenoids of Rosmarinus officinalis and their diacylglycerol acyltransferase-inhibitory activity.[Reference:
WebLink]
Inhibition of acyl CoA:diacylglycerol acyltransferase (DGAT) has been proposed as one of the drug targets for treating obesity and type 2 diabetes.
METHODS AND RESULTS:
Bioassay-guided fractionation of the MeOH-soluble extract of Rosmarinus officinalis yielded two new diacylglycerol acyltransferase (DGAT) inhibitory-abietane diterpenoids, 7β-hydroxy-20-deoxo-rosmaquinone (1) and 7β-methoxy-20-deoxo-rosmanol (2), along with six known components, carnosol (3), 7α-methoxyrosmanol (4),
7beta-Methoxyrosmanol (5), 12-methoxy-canosic acid (6), rosmanol (7), and rosmadial (8).
CONCLUSIONS:
Compounds 1–8 inhibited DGAT1 activity, with the IC50 values ranging from 39.5 ± 0.6 to 144.2 ± 3.1 μM. In particular, carnosol (3), which is one of the major compounds of MeOH-soluble extract of R. officinalis exhibits inhibition of de novo intracellular triacylglycerol synthesis in human hepatocyte HepG2 cells.
