7beta-Methoxyrosmanol | CAS:24703-38-6

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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Abietane diterpenoids of Rosmarinus officinalis and their diacylglycerol acyltransferase-inhibitory activity.[Reference: WebLink]

Inhibition of acyl CoA:diacylglycerol acyltransferase (DGAT) has been proposed as one of the drug targets for treating obesity and type 2 diabetes.
METHODS AND RESULTS:
Bioassay-guided fractionation of the MeOH-soluble extract of Rosmarinus officinalis yielded two new diacylglycerol acyltransferase (DGAT) inhibitory-abietane diterpenoids, 7β-hydroxy-20-deoxo-rosmaquinone (1) and 7β-methoxy-20-deoxo-rosmanol (2), along with six known components, carnosol (3), 7α-methoxyrosmanol (4), 7beta-Methoxyrosmanol (5), 12-methoxy-canosic acid (6), rosmanol (7), and rosmadial (8).
CONCLUSIONS:
Compounds 1–8 inhibited DGAT1 activity, with the IC50 values ranging from 39.5 ± 0.6 to 144.2 ± 3.1 μM. In particular, carnosol (3), which is one of the major compounds of MeOH-soluble extract of R. officinalis exhibits inhibition of de novo intracellular triacylglycerol synthesis in human hepatocyte HepG2 cells.

Product Name	7beta-Methoxyrosmanol
CAS No.:	24703-38-6
Catalog No.:	CFN92990
Molecular Formula:	C₂₁H₂₈O₅
Molecular Weight:	360.44 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Targets:	DGAT1
Source:	The herbs of Rosmarinus officinalis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
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