7,3',4'-Trihydroxyflavone | CAS:2150-11-0

3'4'7-Trihydroxyflavone can markedly inhibit the receptor activator of nuclear factor kappa B ligand (RANKL) induced osteoclastic differentiation from mouse bone marrow derived macrophages (BMMs), it inhibits osteoclastogenesis via nuclear factor of activated T cells c1 (NFATc1).

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3'4'7-Trihydroxyflavone inhibits RANKL-induced osteoclast formation via NFATc1.[Pubmed: 26601423]

3'4'7-Trihydroxyflavone(7,3',4'-Trihydroxyflavone) is a flavonoid from ladino clover, alfalfa, and Albizzia julibrissin .
METHODS AND RESULTS:
In the present study, we found that 3'4'7-trihydroxyflavone markedly inhibited the receptor activator of nuclear factor kappa B ligand (RANKL) induced osteoclastic differentiation from mouse bone marrow derived macrophages (BMMs). 3'4'7-trihydroxyflavone also reduced the mRNA expression level of osteoclastic marker genes including calcitonin receptor (CTR), Cathepsin K, v-ATPase V0 subunit d2 (ATP6v0d2), and dendritic cell-specific transmembrane protein (DC-STAMP). In addition, 3'4'7-trihydroxyflavone decreased the bone resorption activity of osteoclasts on dentin slices. We found that 3'4'7-trihydroxyflavone inhibited RANKL-induced expression of nuclear factor of activated T cells c1 (NFATc1), a key transcription factor of osteoclast differentiation. Furthermore, 3'4'7-trihydroxyflavone attenuated RANKL-induced activation of p38 mitogenactivated protein kinase (MAPK) and expression of B lymphocyte-induced maturation protein 1 (Blimp1), a repressor of negative regulators of NFATc1.
CONCLUSIONS:
Taken together, our data suggest that 3'4'7-trihydroxyflavone inhibits osteoclastogenesis NFATc1.

Product Name	7,3',4'-Trihydroxyflavone
CAS No.:	2150-11-0
Catalog No.:	CFN97786
Molecular Formula:	C₁₅H₁₀O₅
Molecular Weight:	270.24 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Yellow powder
Targets:	p38MAPK \| NF-kB \| ATPase \| RANKL
Source:	The seeds of Cassia occidentalis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:	$118/20mg