Hydroxygenkwanin

Hydroxygenkwanin
Product Name Hydroxygenkwanin
CAS No.: 20243-59-8
Catalog No.: CFN98021
Molecular Formula: C16H12O6
Molecular Weight: 300.3 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Yellow powder
Targets: TNF-α | Caspase | BID | BAK | BCL-XL
Source: The herbs of Lobelia chinensis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $118/20mg
Hydroxygenkwanin has cytotoxicity, may be an effective natural product to treat glioma, and the combination of Apigenin and Hydroxygenkwanin may be a promising method for glioma chemotherapy.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Phytochemistry Letters2015, 243-247
  • Neuropharmacology2019, 151437
  • Heliyon.2023, 9(6):e16138.
  • Int J Mol Sci.2021, 22(10):5181.
  • Sains Malaysiana2022, 51(4):1143-1154
  • Korean Herb. Med. Inf.2021, 9(2):231-239.
  • Int J Mol Sci.2022, 23(23):14545.
  • Pharmacol Res.2022, 182:106346.
  • Int J Nanomedicine.2022, 17:6513-6525.
  • The Journal of Korean Medicine2023, 44(4):26-40.
  • 3,5,6,7,8,4'-hexamethoxyflavone

    Catalog No: CFN91805
    CAS No: 34170-18-8
    Price: Inquiry(manager@chemfaces.com)
    3,3',4',5,6,7,8-heptamethoxyflavone

    Catalog No: CFN95021
    CAS No: 1178-24-1
    Price: $268/10mg
    4'-Hydroxyflavone

    Catalog No: CFN91544
    CAS No: 4143-63-9
    Price: $30/20mg
    4'-Methoxyflavone

    Catalog No: CFN70361
    CAS No: 4143-74-2
    Price: Inquiry(manager@chemfaces.com)
    7-Hydroxy-4'-methoxyflavone

    Catalog No: CFN70378
    CAS No: 487-24-1
    Price: Inquiry(manager@chemfaces.com)
    3',4'-Dihydroxyflavone

    Catalog No: CFN70360
    CAS No: 4143-64-0
    Price: $60/20mg
    3',4'-Dimethoxyflavone

    Catalog No: CFN70359
    CAS No: 4143-62-8
    Price: $70/20mg
    7,3',4'-Trihydroxyflavone

    Catalog No: CFN97786
    CAS No: 2150-11-0
    Price: $118/20mg
    3',4',7,8-Tetrahydroxyflavone

    Catalog No: CFN70342
    CAS No: 3440-24-2
    Price: Inquiry(manager@chemfaces.com)
    Luteolin

    Catalog No: CFN98784
    CAS No: 491-70-3
    Price: $40/20mg
    Chem Biol Interact. 2013 Nov 25;206(2):346-55.
    Synergistic anti-glioma effect of Hydroxygenkwanin and Apigenin in vitro.[Pubmed: 24144774]
    Apigenin (AP) and Hydroxygenkwanin (HGK) are two natural flavonoid compounds. Previous studies have already demonstrated the anti-tumor capability of AP. However, it is not clear whether Hydroxygenkwanin has such property.
    METHODS AND RESULTS:
    In the current study, the anti-glioma activities of Hydroxygenkwanin and its synergistic anti-glioma effects with AP on C6 glioma cells were investigated. In addition, the possible mechanisms were also studied. MTT assay and morphologic analysis including acridine orange/ethidium bromide (AO/EB) and 4',6-diamidino-2-phenylindole (DAPI) staining were used in the research, and the results indicated that the treatment with AP or Hydroxygenkwanin could inhibit C6 glioma cell proliferation respectively. Moreover, when AP was administrated simultaneously, the anti-glioma effect of Hydroxygenkwanin was dramatically enhanced in a dose-dependent manner, which is obviously better than that of carmustine (BCNU) at the concentration 25μM for treating of 24h. Compared with control, mitochondrial membrane potential (MPP) loss and mitochondrion damage were detected by JC-1 fluorescence probes (JC-1) and transmission electron microscopy (TEM) after treatment. Obvious DNA damage and cell cycle S phase arrest were detected by alkaline comet assay and flow cytometric analysis (FCM). Additionally, up regulation of TNF-α level, activations of caspase-3, -8, over expressions of BID and BAK protein and BCL-XL protein down expression were also observed after treatment by the combination of AP and Hydroxygenkwanin .
    CONCLUSIONS:
    The results indicate that Hydroxygenkwanin may be an effective natural product to treat glioma, and the combination of AP and Hydroxygenkwanin may be a promising method for glioma chemotherapy.
    Front Oncol . 2019 Sep 18;9:911.
    Anticancer Effect and Mechanism of Hydroxygenkwanin in Oral Squamous Cell Carcinoma[Pubmed: 31620368]
    Abstract The incidence and mortality of oral squamous cell carcinoma (OSCC) are high, and the number of oral cancers had risen in the world. However, chemotherapy drugs have numerous side effects. There is an urgent requirement to develop a novel drug that can be used to treat oral cancer. Hydroxygenkwanin (HGK) is a nature flavonoid extracted from Daphne genkwa Sieb. et Zucc. (Thymelaeaceae). Previous studies had demonstrated that HGK exhibits anticancer effect, but the effect is still unclear in oral cancer. HGK inhibited cell growth dose-dependently in SAS and OCEM1 cells. The functional enrichment analysis showed the significant pathway in cellular movement, cell cycle and cellular growth and proliferation. We further demonstrated the HGK induced the cell cycle arrest by flow cytometry and inhibited colony formation ability and cell movement. The western blot showed that HGK induced cell cycle arrest through p21 activation and caused intrinsic cell apoptosis pathway. HGK inhibited the cell invasion and migration through down-regulation vimentin. HGK might be an effective natural product for oral cancer therapy. Keywords: RNA sequencing; apoptosis; cell cycle; invasion; migration; oral cancer.
    cis-Mulberroside A

    Catalog No: CFN95006
    CAS No: 166734-06-1
    Price: $368/10mg
    2''-O-acetylsaikosaponin A

    Catalog No: CFN95085
    CAS No: 102934-42-9
    Price: $318/5mg
    Isocarlinoside

    Catalog No: CFN95092
    CAS No: 83151-90-0
    Price: $318/5mg
    Lanceolarin

    Catalog No: CFN95166
    CAS No: 15914-68-8
    Price: $318/5mg
    Isonardosinone

    Catalog No: CFN95180
    CAS No: 27062-01-7
    Price: $318/10mg
    Methylpicraquassioside B

    Catalog No: CFN95379
    CAS No: 1443757-89-8
    Price: $318/10mg
    Tumulosic acid

    Catalog No: CFN95399
    CAS No: 508-24-7
    Price: $368/5mg
    Baishouwubenzophenone

    Catalog No: CFN95473
    CAS No: 115834-34-9
    Price: $318/5mg
    Ganoweberianic acid E

    Catalog No: CFN95504
    CAS No: 1309931-90-5
    Price: $413/5mg
    Methyl ganoderenate F

    Catalog No: CFN95573
    CAS No: N/A
    Price: $413/5mg