6beta-Hydroxystigmast-4-en-3-one
Reference standards.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Front Pharmacol.2021, 12:690113.
Front Microbiol.2023, 14:1232039.
Chemistry of Natural Compounds2019, 55(1):127-130
Asian Pac J Cancer Prev.2019, 20(1):65-72
Analytical Letters.2020, doi 10.1008
Applied Biological Chemistry2023, 66:42.
Curr Issues Mol Biol.2024, 46(4):3328-3341.
Antimicrob Agents Chemother.2020, AAC.01921-20.
Antioxidants (Basel).2022, 11(12):2411.
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China Journal of Chinese Materia Medica, 2007, 32(12):1175-1179.
Chemical constituents from branch of Macaranga adenantha and their TNF-α inhibitory activity.[Reference:
WebLink]
To investigate the chemical constituents of the brach of Macaranga adenantha, and evaluate their TNF-alpha inhibitory activity.
METHODS AND RESULTS:
The chemical conshifuents were isolated and purified by chromatographic methods. Structures of the compounds were identified by spectroscopic methods. The TNF-alpha secretion inhibitory activity of the mouse peritoneal macrophages was evaluated by MTT methods. Ten compounds were isolated and their structures were identified as: cleomiscosin A (1), cleomiscosin B (2), ellagic acid 4-O-alpha-D-rhamnopyranside (3), ellagic acid 4-O-beta-D-xylopyranoside (4), vanillic acid (5), (24R) -stigmast-4-en-3-one (6), (24R) -stigmast-3, 6-dione (7), (24R) -6beta-hydroxy-stigmast-4-en-3-one (6beta-Hydroxystigmast-4-en-3-one
,8), daucosterol (9), beta-sitosteryl glucoside-6'-O-heptadecoicate (10). At a concentration of 10 micromol x L(-1), compounds 1, 3 and 4 showed inhibitory activity to TNF-alpha secretion of the mouse peritoneal macrophages with the inhibitory rates of 57.0%, 64.4%, and 57. 4%, respectively.
CONCLUSIONS:
All compounds were isolated from genus Macaranga for the first time. Compounds 1, 3, and 4 were active against TNF-alpha secretion of the mouse peritoneal macrophages.
Phytochemistry, 1973, 12(4):903-906.
6β-Hydroxy-4-stigmasten-3-one and 6β-hydroxy-4-campesten-3-one.[Reference:
WebLink]
METHODS AND RESULTS:
The first naturally occurring 6-hydroxylated Δ4-3-oxo steroids with intact sterol side chains have been isolated as a molecular complex from the bark extracts of Melia azedarach L. The complex has been characterized by UV, IR, NMR and MS analyses to consist of 6β-hydroxy-4-stigmasten-3-one(6beta-Hydroxystigmast-4-en-3-one) and 6β-hydroxy-4-campesten-3-one, and these structures confirmed by partial synthesis.
