Stigmast-4-ene-3,6-diol
Stigmast-4-ene-3beta,6beta-diol possesses marked inhibitory activity against 12-O-
-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice.
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
BMC Plant Biol.2020, 20(1):214.
J Mol Histol.2019, 50(4):343-354
Biochem Biophys Res Commun.2018, 505(4):1148-1153
Int J Mol Sci.2018, 19(9):E2601
Natural Product Communications2023, 18(9).
Phytomedicine.2016, 23(4):331-9
Appl. Sci.2020, 10,1304
Emirates Journal of Food and Agriculture.2022, 34(6): 528-536.
Enzyme Microb Technol.2022, 161:110111.
J of the Korean Society of Cosmetics and Cosmetology2019, 225-231
Related and Featured Products
Biol. Pharm.Bull.,1995,18(11):1617-9.
Inhibitory effect of some oxygenated stigmastane-type sterols on 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice.[Pubmed:
8593493]
METHODS AND RESULTS:
The oxygenated stigmastane-type sterols stigmastane-3 beta, 6 alpha-diol, stigmastane-3 beta, 6 beta-diol(Stigmast-4-ene-3,6-diol ), 7 alpha-hydroxysitosterol and its diacetyl derivative, 7 beta-hydroxysitosterol and its diacetyl derivative, 7-oxositosterol, 4 beta-hydroxysitosterol, and stigmast-4-ene-3 beta, 6 beta-diol were evaluated with respect to their anti-inflammatory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice.
CONCLUSIONS:
All of the sterols, with the exception of 7 alpha-hydroxysitosterol and its diacetyl derivative, were found to possess marked inhibitory activity. The 50% inhibitory dose of these compounds for TPA-inflammation (1 microgram) was 0.5--1.0 mg/ear.
