Stigmastane-3,6-diol
Stigmastane-3 beta, 6 alpha-diol and stigmastane-3 beta, 6 beta-diol possess marked inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced
inflammation in mice, the 50% inhibitory dose is 0.5--1.0 mg/ear.
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Applied Biological Chemistry 2022, 65,5(2022).
J Biomol Struct Dyn.2022, 5;1-17.
Integrative Medicine Research2024, 13(1):101025.
Molecules.2018, 23(7):E1817
Journal of Apicultural Research2021, 60(1)
J Sep Sci.2018, 41(11):2488-2497
J Cachexia Sarcopenia Muscle.2022, 13(6):3149-3162.
J Sep Sci.2019, 42(21):3352-3362
Biomed Pharmacother.2024, 174:116598.
Sci Rep.2019, 9:12132
Related and Featured Products
Biol Pharm Bull. 1995 Nov;18(11):1617-9.
Inhibitory effect of some oxygenated stigmastane-type sterols on 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice.[Pubmed:
8593493]
METHODS AND RESULTS:
The oxygenated stigmastane-type sterols stigmastane-3 beta, 6 alpha-diol(Stigmastane-3,6-diol), stigmastane-3 beta, 6 beta-diol, 7 alpha-hydroxysitosterol and its diacetyl derivative, 7 beta-hydroxysitosterol and its diacetyl derivative, 7-oxositosterol, 4 beta-hydroxysitosterol, and stigmast-4-ene-3 beta, 6 beta-diol were evaluated with respect to their anti-inflammatory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice.
CONCLUSIONS:
All of the sterols, with the exception of 7 alpha-hydroxysitosterol and its diacetyl derivative, were found to possess marked inhibitory activity. The 50% inhibitory dose of these compounds for TPA-inflammation (1 microgram) was 0.5--1.0 mg/ear.
Planta Med 2008; 74 - P-101
Chemical Studies of Casearia sylvestris Swartz[Reference:
WebLink]
METHODS AND RESULTS:
In the present report, the isolation and structure elucidation of two new highly oxygenated clerodane diterpenes casearins U and V (1 and 2) and two new ent -kauranoid diterpene glycosides sylvestriside A and B (3 and 4) were described from C. sylvestris (see Fig. 1), together with 3 known diterpenes, namely, (−)-hardwickic acid (5), (−)-patagonic acid (6) and ent-3β, 18-dihydroxykaur-16-ene (7), as well as 11 other known compounds, namely, spathulenol (8), 7, 8-dihydrovomifoliol (blumenol B 9), N-methyl-trans-4-hydroxy-L-proline (10), Cinnamic acid (11), Soyacerebroside I (12), methypheophorbides (13), pheophorbide a (14), chlorophyll (15), β-sitosterol (16), Stigmastane-3,6-diol (17), daucosterol (18), β-D-glucopyranoside, (3β)-stigmast-5-en-3-yl, 6-nonadecanoate (19).
