5,7,4'-Trimethoxyafzelechin
5,7,4'-Trimethoxyafzelechin is a natural product from Celastrus orbiculatus.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Eur Rev Med Pharmacol Sci.2020, 24(9):5127-5139.
Nutrients.2021, 13(8):2901.
Mie University2019, 10076.
Journal of Medical Sciences2024, 44(5):p 222-227.
Arch Biochem Biophys.2020, 687:108384.
Sci Rep.2020, 10:4495(2020)
Vietnam J. Chemistry2022, 60(2):211-222
J Anal Methods Chem.2024, 2024:7703951.
ACS Omega.2024, 9(41):42227-42244.
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J Oleo Sci. 2008;57(8):431-5.
Alpha-glucosidase inhibitor from Bergenia ligulata.[Pubmed:
18622126]
Inhibitory compound of alpha-glucosidase activity, (+)-afzelechin (1), was isolated from rhizomes of Bergenia ligulata.
METHODS AND RESULTS:
The structure was identified by IR, EI-MS, (1)H and (13)C NMR spectroscopy. The ID(50) (50% inhibition dose) value of compound 1 was 0.13 mM. To investigate the structure-activity relationship, (+)-afzelechin tetraacetate (2), (+)-5,7,4'-Trimethoxyafzelechin (3), (+)-tetramethoxyafzelechin (4), and (+)-3-acetyl-5,7,4'-Trimethoxyafzelechin (5) as the derivatives of compound 1 were evaluated as well.
