29-Nor-20-oxolupeol
29-Nor-20-oxolupeol(3 beta-Hydroxy-30-norlupan-20-one) has growth inhibitory effects on HL-60 cells.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Zhongguo Zhong Yao Za Zhi. 2008 Jun;33(12):1422-4.
Studies on chemical constituents from Euonymus alatus II[Pubmed:
18837347]
To study the chemical constituents and antitumor activities of Euonymus alatus.
METHODS AND RESULTS:
Compounds were isolated and purified repeatedly by silica gel, Sephadex LH-20 column chromatography, and their chemical structures were elucidated by their physicochemical properties and spectral data, such as 1H-NMR, 13C-NMR and EI-MS. The trypan blue experiments in vitro were used to observe the antitumor activity of several compounds. Ten compounds were obtained and identified as (+)-usnic acid (1), benzoic acid (2), 2-hydroxy-4-methoxy-3, 6-dimethyl benzoic acid (3), lupeol (4), 3 beta-hydroxy-30-norlupan-20-one (29-Nor-20-oxolupeol,5), (2R, 3R)-3, 5, 7, 4'-tetrahydroxy flavanone (6), kaempferol (7), 5, 7, 4'-trihydroxy flavanone (8), quercetin (9) and daucosterol (10).
CONCLUSIONS:
Compounds 1, 2, 5 and 8 were isolated from this genus for the first time. The trypan blue experiments in vitro showed that compounds 1, 4 and 5 had growth inhibitory effects on HL-60 cells.
Canadian Journal of Chemistry,2011,86(4):281-4.
Triterpenoids from Saussurea ussuriensis[Reference:
WebLink]
METHODS AND RESULTS:
From an extract of the whole plant of Saussurea ussuriensis, three new triterpenoids, 1β-hydroxy-ursa-9(11), 12-dien-3β-yl palmitate (ussuriensin A) (1), 1β-hydroxy-oleana-9(11), 12-dien-3β-yl palmitate (ussuriensin B) (2), and 28-hydroxy-taraxast-20(30)-ene-3β-yl palmitate (ussuriensin C) (3), as well as five known triterpenoids, 11β-hydroxy-urs-12-en-3-one (4), 11β-hydroxy-urs-12-en-3β-yl palmitate (5), ursa-9(11), 12-dien-3-one (marsformosanone) (6), 3β-hydroxy-30-norlupan-20-one (29-Nor-20-oxolupeol,7), and taraxast-20(30)-en-3β, 21α-diol (8) were isolated. Their structures were characterized by various spectroscopic methods, including 1D NMR, 2D NMR, and HR-ESI-MS.Key words: Compositae, Saussurea ussuriensis, triterpenoids, ursane, oleanane, taraxastane.
