2-Hydroxy-3-methoxybenzoic acid glucose ester

2-Hydroxy-3-methoxybenzoic acid glucose ester
Product Name 2-Hydroxy-3-methoxybenzoic acid glucose ester
CAS No.: 172377-87-6
Catalog No.: CFN89113
Molecular Formula: C14H18O9
Molecular Weight: 330.28 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Powder
Targets: PAFR
Source: The whole plants of Gentiana scabra.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Price: $268/5mg
2-Hydroxy-3-methoxybenzoic acid glucose ester shows a potent antagonistic activity against platelet activating factor (PAF), it can prevent the mice from the PAF-induced death at a dose of 300 micrograms/mouse.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Arch Pharm Res. 1998 Aug;21(4):436-9.
    PAF antagonistic activity of 2-hydroxy-3-methoxybenzoic acid glucose ester from Gentiana scabra.[Pubmed: 9875472]
    In order to find out anti-platelet activating factor (PAF) from natural resources, Korean medicinal plants used for the treatments of peripheral circulation disorders were tested for their possible protective effects on PAF-induced anaphylactic shock.
    METHODS AND RESULTS:
    From the above screening, the methanol extract of Gentiana scabra showed a potent antagonistic activity against PAF. Water suspension of the extract was partitioned with CH2Cl2 and EtOAc, successively. The EtOAc fraction which showed the highest activity was chromatographed on silica gel to yield 6 fractions. From the fraction which showed higher PAF-antagonistic activity than the other fractions, compound 1 was isolated by recrystallization.
    CONCLUSIONS:
    On the basis of spectral data, compound 1 was identified as 2-Hydroxy-3-methoxybenzoic acid glucose ester. The compound prevented the mice from the PAF-induced death at a dose of 300 micrograms/mouse.
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