14-Deoxy-11-hydroxyandrographolide
14-Deoxy-11-hydroxyandrographolide shows potent cell differentiation-inducing activity towards mouse myeloid leukemia (M1) cells.
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Enzyme Microb Technol.2019, 122:64-73
Biomed Pharmacother.2024, 171:116166.
J Med Food.2016, 19(12):1155-1165
Allergol Immunopathol (Madr).2022, 1;50(4):23-30.
Fitoterapia.2024, 175:105955.
Biochem Systematics and Ecology2017, 11-18
Molecules.2021, 26(9):2802.
Biol Pharm Bull.2020, 43(10):1534-1541.
J Pharm Biomed Anal.2024, 241:115990.
Journal of Ginseng Research2021, 25 November
Related and Featured Products
Chem Pharm Bull (Tokyo). 1994 Jun;42(6):1216-25.
Cell differentiation-inducing diterpenes from Andrographis paniculata Nees.[Pubmed:
8069972]
The methanol extract of the aerial part of Andrographis paniculata Nees showed potent cell differentiation-inducing activity on mouse myeloid leukemia (M1) cells.
METHODS AND RESULTS:
From the ethyl acetate-soluble fraction of the methanol extract, six new diterpenoids of ent-labdane type, 14-epi-andrographolide (3), isoandrographolide (4), 14-deoxy-12-methoxyandrographolide (7), 12-epi-14-deoxy-12-methoxyandrographolide (8), 14-deoxy-12-hydroxyandrographolide (9) and 14-Deoxy-11-hydroxyandrographolide (10) as well as two new diterpene glucosides, 14-deoxy-11,12-didehydroandrographi-side (12) and 6'-acetylneoandrographolide (14), and four new diterpene dimers, bis-andrograpolides A (15), B (16), C (17) and D (18), were isolated along with six known compounds. The structures of the diterpenoids were determined by means of spectral methods.
CONCLUSIONS:
Some of these compounds showed potent cell differentiation-inducing activity towards M1 cells.
