12-Hydroxysapriparaquinone
12-Hydroxysapriparaquinone is a natural product from Salvia prionitis.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Antioxidants (Basel).2020, 9(2):E120
J Appl Toxicol.2024, jat.4615.
Phytomedicine.2024, 128:155527.
Heliyon.2024, 10(7):e28364.
Antioxidants (Basel).2020, 9(4):284.
Biomed Pharmacother.2023, 166:115329.
J Ethnopharmacol.2024, 335:118628.
Separations2023, 10(7), 411.
J Ethnopharmacol.2020, 269:113752.
J Ethnopharmacol.2020, 249:112381
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Records of Natural Products, 2007 , 1 (1) :1-16.
Biological activity of diterpenoids isolated from Anatolian Lamiaceae Plants[Reference:
WebLink]
METHODS AND RESULTS:
Since Salvia species, especially Chinese sage S. milthiorrhiza has been used in the treatment of coronary heart diseases, Prof. Ulubelen group also investigated cardiovascular properties of several Salvia extracts (S. amplexicaulis, S. eriophora and S. syriaca) and their constituents in vivo, on Wistar Albino rats [5, 40-42]. The crude extract of S. eriophora and isolated eleven diterpenoids ferruginol (11), aethiopinone (56), 4,12-dihydroxysapriparaquinone (63), 6,7-didehydroroyleanone (64) and 4,14-dihydroxysaprorthoquinone (65), horminone, acetylhorminone, salvipisone, 12-Hydroxysapriparaquinone, 3,12-dihydroxysapri-paraquinone-1-ene, salvilimbinol, were tested [40] for cardiovascular activity.
CONCLUSIONS:
Among the tested abietanes, compounds 65, 56, 11, 63 and 64 as well as the crude extract showed antihypertensive activity, especially ferruginol, aethiopinone and 4,12- dihydroxysapriparaquinone by significantly reducing arterial blood pressure, and this activity is considered probably due to the vasorelaxation activity [5].
