1beta-Hydroxyalantolactone
1beta-Hydroxyalantolactone has protective effect against AD-like skin inflammation, can as a potential therapeutic agent for AD.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Aug 15;903:40-5.
Simultaneous determination of three sesquiterpene lactones from Herba Inula extract in rat plasma by LC/MS/MS and its application to pharmacokinetic study.[Pubmed:
22819204]
METHODS AND RESULTS:
A rapid and sensitive liquid chromatography-tandem mass spectrometry method has been developed and validated for the determination of 1-acetoxy-6α-hydroxyeriolanolide, 1beta-Hydroxyalantolactone and ivangustin from Herba Inula extract in rat plasma. Calibration curves were linear over the concentration range of 4-800 ng/mL for 1-acetoxy-6α-hydroxyeriolanolide, 8-500 ng/mL for 1beta-Hydroxyalantolactone and ivangustin. The limit of detection (LOD) was 1 ng/mL for 1-acetoxy-6α-hydroxyeriolanolide, 1.6 ng/mL for 1beta-Hydroxyalantolactone and ivangustin (S/N=3).
CONCLUSIONS:
The method was successfully applied to pharmacokinetic studies of the three sesquiterpene lactones after oral administration of 300 mg/kg Herba Inula extract to rats, the t(½) of 1-acetoxy-6α-hydroxyeriolanolide, 1beta-Hydroxyalantolactone and ivangustin was 9.65±1.43, 14.88±0.82 and 13.93±2.74 (h). The AUC((0-t)) of 1-acetoxy-6α-hydroxyeriolanolide, 1beta-Hydroxyalantolactone and ivangustin was 1102.46±247.04, 808.92±117.53 and 990.35±275.49 (ng h/mL), respectively.
Pharm Biol. 2015 May 28:1-7.
1β-Hydroxyalantolactone, a sesquiterpene lactone from Inula japonica, attenuates atopic dermatitis-like skin lesions induced by 2,4-dinitrochlorobenzene in the mouse.[Pubmed:
26017682]
1beta-Hydroxyalantolactone (IJ-5) is a sesquiterpene lactone compound isolated from Inula japonica Thunb (Asteraceae). Sesquiterpene lactones have been shown to modulate many processes that influence inflammatory reactions. The present study examines the protective effect of 1beta-Hydroxyalantolactone on atopic dermatitis (AD) in a mouse model induced by 2,4-dinitrochlorobenzene (DNCB).
METHODS AND RESULTS:
1beta-Hydroxyalantolactone was administrated intraperitoneally at 10 mg/kg 1 h before each DNCB challenge. RESULTS: 1beta-Hydroxyalantolactone treatment attenuated DNCB-induced dermatitis severity and right ear swelling. The serum levels of IgE, IL-4, and IL-6 in 1beta-Hydroxyalantolactone-treated mice were reduced by 54.7, 56.5, and 53.0%, respectively, while the mRNA levels of TNFα, IL-1, IL-4, and IL-6 in back skin lesions of 1beta-Hydroxyalantolactone-treated mice were reduced by 47.7, 61.5, 57.5, and 58.5%, respectively, compared with untreated controls. Histopathological examination showed that 1beta-Hydroxyalantolactone treatment decreased DNCB-induced hypertrophy, hyperkeratosis, and infiltration of inflammatory cells in both ear and back skins. Moreover, 1beta-Hydroxyalantolactone suppressed the expression of TNFα, IL-1, and IL-6 with IC50 values of 6.58, 9.48, and 7.01 μM, respectively, and inhibited the activation of NF-κB pathway in TNFα-stimulated HaCat cells.
CONCLUSIONS:
The present study demonstrates the protective effects of 1beta-Hydroxyalantolactone against AD-like skin inflammation and highlights 1beta-Hydroxyalantolactone as a potential therapeutic agent for AD.
