Hot Products

Kobusin
Catalog No: CFN89280

Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflammatory diseases through the inhibition of iNOS expression and peroxynitrite scavenging potential. Kobusin can mildly reduce gastrointestinal motility in mice, it activates CFTR and CaCCgie chloride channel activities in mouse colonic epithelia and shows inhibitory effects toward ANO1/CaCC-mediated short-circuit currents in ANO1/CaCC-expressing FRT cells.

Kobusone
Catalog No: CFN98253

Reference standards.

Kojic acid
Catalog No: CFN94478

Kojic acid has been used as a food additive for preventing enzymatic browning of crustaceans and as a cosmetic agent for skin whitening. Kojic acid exhibits concentration-dependent scavenging activity on DPPH possessing strong antioxidant activity, it can reduce the mortality induced by gamma irradiation; it exhibits a competitive inhibition for the oxidation of chlorogenic acid and catechol by potato polyphenol oxidase (PPO) and of 4-methylcatechol and chlorogenic acid by apple PPO; it also has significant tyrosinase inhibitory activity.

Kolavenol
Catalog No: CFN97792

Kolavenol shows a trypanocidal activity with an IC50 value of 2.5 microg/ml (8.6 microM) against Trypanosoma brucei rhodesiense, the causing agent of the acute form of human African trypanosomiasis.

Kongensin A
Catalog No: CFN97452

Kongensin A is an effective heat shock protein 90 (HSP90) inhibitor that has potential anti-necroptosis and anti-inflammation applications.

Koumine
Catalog No: CFN99425

Koumine shows potent anti-tumor, anxiolytic, antistress, antipsoriatic, and analgesic activities, it also protects against the development of arthritis in Rheumatoid arthritis (RA) animal models.Koumine can induce apoptosis of LoVo cells in a time-dependent manner and inhibit the DNA synthesis in LoVo cells, thereby blocking the cell cycle from G1 to S phase.

Koumine N-oxide
Catalog No: CFN97937

Koumine N-oxide is a natural product from Gelsemium elegans.

Kuguacin J
Catalog No: CFN92073

Kuguacin J is a promising candidate new antineoplastic and chemopreventive agent for androgen-dependent prostate cancer and carcinogenesis, it exerts growth inhibition through G1 arrest and induction of apoptosis in androgen-dependent human prostate cancer. Kuguacin J modulates the function of P-glycoprotein (P-gp) by directly interacting at the drug-substrate-binding site, and it appears to be an effective inhibitor of P-gp activity in vitro and thus could be developed as an effective chemosensitizer to treat multidrug-resistant cancers.

Kuguacin N
Catalog No: CFN92074

Kuguacin N has antioxidant activity.

Kuguaglycoside C
Catalog No: CFN92309

Kuguaglycoside C induces caspase-independent cell death, and is involved, at least in part, in the mechanism underlying cell necroptosis.