erythro-Guaiacylglycerol-beta-O-4'-dehydrodisinapyl ether
erythro-Guaiacylglycerol-β-O-4'-dehydrodisinapyl ether shows inhibitory activity against human leukocyte elastase with the IC50 value of 171 umol·L-1.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Chemical constituents of the seed shell of Hevea brasiliensis.[Reference:
WebLink]
To study the chemical constituents of the seed shell of Hevea brasiliensis.
METHODS AND RESULTS:
The compounds were isolated by chromatography on silica gel, LH-20, ODS-C18 and HPLC. Their structures were identified by physicochemical and spectral analysis. MTT assays in vitro were used to explore the inhibitory effect of these compounds on B16 cancer cells, and a high through-put screening method was used to explore the HLE inhibitors. Nine compounds were isolated and identified as vanillin(1), coniferaldehyde(2), erythro-guaiacylglycerol-β-coniferyl aldehyde ether(3), threo-guaiacylglycerol-β-coniferyl aldehyde ether(4), (-)-balanophonin(5), isoamericanol A (6), americanol A (7),erythro-Guaiacylglycerol-beta-O-4'-dehydrodisinapyl ether (8), and buddlenol A (9). Compound 9 showed anti-tumor activity against B16 cancer cells with IC50 value of 20.6 μmol·L-1. Compounds 5~9 showed inhibitory activity against human leukocyte elastase with IC50 values of 168, 45.5, 57.6, 171 and 115 μmol·L-1, respectively.
CONCLUSIONS:
All compounds were isolated from this plant for the first time. Compound 9 showed inhibitory activity on B16 cancer cells, and compounds 5~9 were reported as human leukocyte elastase inhibitors for the first time.
