erythro-Guaiacylglycerol-beta-O-4'-dehydrodisinapyl ether

erythro-Guaiacylglycerol-beta-O-4'-dehydrodisinapyl ether
Product Name erythro-Guaiacylglycerol-beta-O-4'-dehydrodisinapyl ether
CAS No.: 613684-55-2
Catalog No.: CFN96718
Molecular Formula: C31H36O11
Molecular Weight: 584.61 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Powder
Source: The seed shell of Hevea brasiliensis.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
erythro-Guaiacylglycerol-β-O-4'-dehydrodisinapyl ether shows inhibitory activity against human leukocyte elastase with the IC50 value of 171 umol·L-1.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Chinese Journal of New Drugs, 2012, 21(19):2311-2315.
    Chemical constituents of the seed shell of Hevea brasiliensis.[Reference: WebLink]
    To study the chemical constituents of the seed shell of Hevea brasiliensis.
    METHODS AND RESULTS:
    The compounds were isolated by chromatography on silica gel, LH-20, ODS-C18 and HPLC. Their structures were identified by physicochemical and spectral analysis. MTT assays in vitro were used to explore the inhibitory effect of these compounds on B16 cancer cells, and a high through-put screening method was used to explore the HLE inhibitors. Nine compounds were isolated and identified as vanillin(1), coniferaldehyde(2), erythro-guaiacylglycerol-β-coniferyl aldehyde ether(3), threo-guaiacylglycerol-β-coniferyl aldehyde ether(4), (-)-balanophonin(5), isoamericanol A (6), americanol A (7),erythro-Guaiacylglycerol-beta-O-4'-dehydrodisinapyl ether (8), and buddlenol A (9). Compound 9 showed anti-tumor activity against B16 cancer cells with IC50 value of 20.6 μmol·L-1. Compounds 5~9 showed inhibitory activity against human leukocyte elastase with IC50 values of 168, 45.5, 57.6, 171 and 115 μmol·L-1, respectively.
    CONCLUSIONS:
    All compounds were isolated from this plant for the first time. Compound 9 showed inhibitory activity on B16 cancer cells, and compounds 5~9 were reported as human leukocyte elastase inhibitors for the first time.
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