Meliasendanin D
Meliasendanin D is a natural product from Melia toosendan.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Fitoterapia. 2014 Dec;99:92-8.
Neolignans, lignans and glycoside from the fruits of Melia toosendan.[Pubmed:
25250895 ]
Four new neolignans, meliasendanin A, meliasendanin B, meliasendanin C,Meliasendanin D (1-4), and a new glycoside, toosenoside A (5), together with ten known ones (6-15), were isolated from a n-BuOH partition of the fruits of Melia toosendan.
METHODS AND RESULTS:
Their structures were elucidated by analyses of extensive spectroscopic data and comparison of the NMR data with those reported previously. Meliasendanin A (1) was a rare neolignan containing isochroman moiety, and its absolute configuration was determined using a CD spectrum. Toosenoside A (5) was an unusual glycoside with a rare naturally occurring aglycone and its structure was confirmed by X-ray single crystal diffraction analysis.
The antioxidant activity of the isolated neolignans and lignans was evaluated by ABTS radical-scavenging assay.
CONCLUSIONS:
Compounds 1 and 13 exhibited strong antioxidant activity, with IC₅₀ values of 62.8 and 45.1 μM, respectively.
