ent-16alpha,17-Dihydroxyatisan-3-one | CAS:112523-91-8

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

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Separations2023, 10(11), 567;

Anticancer Res. 2009 Nov;29(11):4467-72.

Multidrug resistance modulation and apoptosis induction of cancer cells by terpenic compounds isolated from Euphorbia species.[Pubmed: 20032393]

One of the most promising strategies to overcome multidrug resistance (MDR) is to use compounds that can modulate P-glycoprotein and restore the cytotoxicity of anticancer drugs. Furthermore, the search for compounds that regulate and overcome apoptosis deficiency of cancer cells is also of great therapeutic importance.
METHODS AND RESULTS:
Seven known pentacyclic triterpenes and one steroid were isolated from Euphorbia lagascae methanolic extracts and identified by physical and spectroscopic methods. These compounds, together with eleven terpenoids previously isolated from Euphorbia lagascae and E. tuckeyana were tested for their MDR-reversing and/or apoptosis induction activities by flow cytometry on L5178 human MDR1 gene-transfected mouse lymphoma cells. Four taraxastane-type triterpenes: 21alpha-hydroxytaraxasterol, 21alpha-hydroxytaraxasterol acetate, 3beta,30-dihydroxy-20(21)-taraxastene and 3beta-hydroxy-20-taraxasten-30-al, and two steroids: stigmastane-3,6-dione and ergosterol peroxide exhibited a significant MDR-Pgp modulation activity. Some aspects of structure-activity relationships are discussed.
CONCLUSIONS:
Regarding apoptosis induction, the most significant results were obtained for the polycyclic diterpenes ent-16alpha,17-dihydroxykauran-3-one and ent-16alpha,17-Dihydroxyatisan-3-one.

Journal of Kunming University of Science and Technology(Natural Science Edition),2013,38(6):93-5.

Diterpenoids from Euphorbia Antiquorum.[Reference: WebLink]

METHODS AND RESULTS:
By the means of chromatographic methods and spectroscopic evidences,6 known compounds were isolated and identified from the EtOAc extract of E. antiquorum. Their structures were identified respectively as 13β-hydroxy-3,15-dioxoatis-16-ene( 1),ent-16α,17-dihydroxykauran-3-one( 2),ent-16α, 17-dihydroxyatisan-3-one(ent-16alpha,17-Dihydroxyatisan-3-one,3),ent-3β( 13S),17-dihydroxyatisan-16-en-14-one( 4),6,7,8-trimethoxyl-coumarin( 5),and β-sitosterol( 6).
CONCLUSIONS:
Compounds 1-4 were ent-kaurane or atisane diterpenoids,which were isolated from this plant for the first time.

Product Name	ent-16alpha,17-Dihydroxyatisan-3-one
CAS No.:	112523-91-8
Catalog No.:	CFN96312
Molecular Formula:	C₂₀H₃₂O₃
Molecular Weight:	320.5 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Targets:	P-gp
Source:	The herbs of Euphorbia Antiquorum.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
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