Tupichinol A
Tupichinol A is a natural product from Tupistra chinensis.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Phytomedicine.2021, 84:153501.
Toxicological Research2020, doi: 10.1007.
Microbiol. Biotechnol. Lett.2022, 50(2): 193-201.
Int J Mol Sci.2017, 18(5)
J Ethnopharmacol.2019, 244:112074
Journal of Food Quality2022, P:13, 6256310.
Biomol Ther (Seoul).2020, 28(6):542-548.
J Cell Mol Med.2023, 27(10):1423-1435.
Separations2021, 8(6),80.
Nat Prod Sci.2014, 20(3):182-190
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J Nat Prod. 2003 Feb;66(2):161-8.
New flavans, spirostanol sapogenins, and a pregnane genin from Tupistra chinensis and their cytotoxicity.[Pubmed:
12608845]
METHODS AND RESULTS:
Seven new compounds, including three new flavans [Tupichinol A,tupichinol B, tupichinol C (1-3)], three new spirostanol sapogenins [tupichigenin D, tupichigenin E, tupichigenin F (4-6)], and one new pregnane genin [tupipregnenolone (7)], together with 18 known compounds, were isolated from the underground parts of Tupistra chinensis. The structures of the new compounds were elucidated by spectroscopic analysis and chemical evidence.
The structures and relative stereochemistry of 1 and 9 were further confirmed by single-crystal X-ray crystallographic analysis.
CONCLUSIONS:
Compounds Delta(25(27))-pentrogenin, 10, and ranmogenin A showed 100%, 96%, and 80% inhibition, respectively, against human gastric tumor (NUGC) cells at a concentration of 50 microM. Delta(25(27))-pentrogenin showed 100% inhibition against human nasopharyngeal carcinoma (HONE-1) cells at a concentration of 50 microM.
