Toonaciliatin M
Toonaciliatin M shows moderate antifungal activity against Trichophyton rubrum (MIC = 12.5 microg/mL). It shows moderate inhibitory activity against lipopolysaccharide-induced nitric oxide production in RAW264.7 cells.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Chinese Traditional & Herbal Drugs, 2014, 45(6):755-759.
Chemical constituents from Toona ciliata var. henryi and their anti-inflammatory activities.[Reference:
WebLink]
To study the chemical constituents from Toona ciliata var. henryi and their bioactivities.
METHODS AND RESULTS:
Column chromatography on silica gel, RP-C18, and Sephadex LH-20 columns was used to separate and purify the chemical constituents. The structures were elucidated by physicochemical properties and spectroscopic analyses. These compounds were isolated and evaluated for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells. Fifteen compounds were isolated from the stem barks of T. ciliata var. henryi and identified as odoratone (1), toonaciliatin F (2), toonaciliatin G (3), toonaciliatin J (4), hispidone (5), bourjotinolone A (6), 3-episapeline A (7), piscidinol A (8), aglaiodiol (9), Toonaciliatin M (10), 2α, 19-dihydroxy-9-epi-ent-pimara-7, 15-diene (11), cleomiscosin B (12), cleomiscosin C (13), β-sitosterol (14), and β-daucositerol (15). The IC50 values of compounds 4 and 10 were (11.0 ± 0.7) and (28.8 ± 2.7) μmol/L.
CONCLUSIONS:
All the compounds are isolated from this plant for the first time. Compounds 11-13 are yielded from the plants of Toona Roem. for the first time. Compounds 4 and 10 show the moderate inhibitory activities.
J Nat Prod. 2009 Apr;72(4):685-9.
Terpenoids from Toona ciliata.[Pubmed:
19275174]
METHODS AND RESULTS:
Three new norlimonoids (1-3), two new tirucallane-type triterpenoids (4 and 5), and a new pimaradiene-type diterpenoid (6), along with two known limonoids and eight known tirucallane-type triterpenoids, were isolated from the leaves and twigs of Toona ciliata. Their structures were elucidated on the basis of spectroscopic data.
CONCLUSIONS:
Toonaciliatin M (6) showed moderate antifungal activity against Trichophyton rubrum with an MIC of 12.5 microg/mL.
