Hugorosenone
Hugorosenone has antifungal activity. It also exhibits activity against Anopheles gambiae mosquito larvae.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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J Cell Biochem.2018, 119(2):2231-2239
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J of the Korean Society of Food Science and Nutrition2016, 45(7):1017-1025
Eur Endod J.2020, 5(1):23-27.
Int. J of Herbal Med.2023, 11(1): 06-14
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Phytochemistry. 2008 Jan;69(1):200-5.
Antifungal rosane diterpenes and other constituents of Hugonia castaneifolia.[Pubmed:
17688894]
METHODS AND RESULTS:
The rosane diterpenoids Hugorosenone [3beta-hydroxyrosa-1(10),15-dien-2-one], 18-hydroxyHugorosenone and 18-hydroxy-3-deoxyHugorosenone, and 12-hydroxy-13-methylpodocarpa-8,11,13-trien-3-one were isolated as antifungal constituents of H. castaneifolia Engl. root bark, together with the previously reported di-podocarpanoids hugonone A and hugonone B that were weakly active, and 1(10),15-rosadiene-2beta,3beta-diol (hugorosenol), 4alpha-methoxyhimachal-10-en-5beta-ol (hugonianene B) and 2-hydroxyhenpentacont-2-enal, and the known compounds tetracosyl-(E)-ferrulate and caryophyllene oxide, all of which were inactive.
CONCLUSIONS:
Hugorosenone also exhibited activity against Anopheles gambiae mosquito larvae. Structural determination was achieved based on spectroscopic data.
