Taxinine
Taxinine and Taxinine B can inhibit the drug transport by P-glycoprotein in multidrug-resistant cells.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Tetrahedron, 1997, 53(13):4621-4626.
Crystal and solution state conformations of two taxoids, taxinine and taxinine B[Reference:
WebLink]
METHODS AND RESULTS:
Crystal and solution state conformations of two taxoids, Taxinine and Taxinine B, inhibiting the drug transport by P-glycoprotein in multidrug-resistant cells, were analyzed by X-ray crystallographic analysis and ROE experiments. This study demonstrated that in solid state, both Taxinine and Taxinine B took similar cage conformation in which A-ring and the cinnamoyl side chain at C-ring were specially very close to each other.
CONCLUSIONS:
These conformations were also observed in their solution conformations deduced by ROE correlations in CDCl3, Monte Carlo simulation using MM2∗ force field, and semiempirical molecular orbital calculation using PM3 method.
Natural Product Research & Development, 2004, 18(12):160-160.
STUDIES ON CHEMICAL CONSTITUENTS OF SEEDS OF TUXUS MAIREI (Ⅰ)[Reference:
WebLink]
One sterol and nine taxane diterpenoids β-sitosterol(1),5α-cinnamoyloxy-9α,10β,13α-triacetoxy-taxa-4(20),11-diene(2),Taxinine(3),Taxinine J(4),Taxinine B(5),Taxinine E(6),10-deacetylTaxinine(7),taxuspine W(8),decinnamoylTaxinine E(9)and taxol(10)were isolated from the seeds of T.mairei.Except compounds 2,3,4,all the compounds were obtained from the seeds of this plant for the first time.
