Tasumatrol L
Tasumatrol L is a natural product from Taxus sumatrana.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Int J Mol Sci.2022, 23(11):6104.
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Revista Brasileira de Farmacognosia2021, 31:794-804.
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bioRxiv - Biochemistry2023, 541790.
Front Immunol.2018, 9:2091
Kor.J.Herbol.2024, 39(3):23-35
Institute of Food Science & Technology2021, 45(9).
Elife.2021, 10:e68058.
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Tetrahedron, 2005, 61(5):1345-1352.
Novel taxane diterpenes from Taxus sumatrana with the first C-21 taxane ester.[Reference:
WebLink]
METHODS AND RESULTS:
Phytochemical investigation of the taxane diterpenes content of an acetone extract of the leaves and twigs of Taxus sumatrana (Taxaceae) has resulted in the isolation of five new taxane diterpenes esters, tasumatrol H, tasumatrol I, tasumatrol J, tasumatrol K, Tasumatrol L (1–5) together with 13 known taxanes (11–23). Compound 5 is the first 21-carbon taxane ester to be isolated from a natural source. The structures of these taxanes as well as their derivatives were established on the basis of spectral analyses, especially MS as well as 1-and 2D NMR.
CONCLUSIONS:
Compounds 2 and 4 showed significant activity against human liver carcinoma (Hepa59T/VGH), human large cell carcinoma of the lungs (NCI), human cervical epitheloid carcinoma (Hela), human colon adenocarcinoma (DLD-1) and human medulloblastoma (Med) cell lines.
