Taxumairol B
Taxumairol B is a natural product from Taxus yunnanensis.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Evid Based Complement Alternat Med.2017, 2017:1583185
Arch Biochem Biophys.2024, 759:110111.
Molecules.2023, 28(17):6315.
Applied Biological Chemistry2022, 71:s13765-022-00743-5.
J Physiol Biochem.2024, 80(2):421-437.
Mol Cells.2015, 38(9):765-72
Metabolites2022, 12(6),507.
Phytomedicine.2018, 41:62-66
FASEB J.2022, 36(7):e22387.
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J Nat Prod. 1996 Feb;59(2):173-6.
New taxane diterpenoids from the roots of Taxus mairei.[Pubmed:
8991951 ]
METHODS AND RESULTS:
Two new taxoids, taxumairol A (1) and Taxumairol B (2), have been isolated from extracts of the roots of Formosan Taxus mairei (Lemee & Levl.) S. Y. Hu. The structures of 1 and 2 were identified as 5 alpha, 7 beta, 9 alpha, 10 beta, 13 alpha-pentaacetoxy-20-(benzoyloxy)- 2 alpha, 4 alpha-dihydroxytax-11-ene and 2 alpha, 5 alpha, 10 beta,-13 alpha-tetraacetoxy-1 beta, 7 beta, 9 alpha-trihydroxy-4 beta,20-epoxytax-11-ene, primarily on the basis of 1D- and 2D-NMR techniques including DEPT, COSY, and HMBC experiments, as well as chemical correlation with known compounds.
CONCLUSIONS:
Taxumairol A (1) exhibited significant cytotoxicities against murine P-388 and human KB-16, A-549, and HT-29 tumor cell lines.
Chinese Traditional & Herbal Drugs, 2013, 44(11):1380-1385.
Chemical constituents from seeds of Taxus yunnanensis.[Reference:
WebLink]
To study the chemical constituents from the seeds of Taxus yunnanensis.
METHODS AND RESULTS:
The chemical constituents in the seeds of T. yunnanensis were isolated by chromatography and identified by a comprehensive analysis on the spectral data. Twelve taxanes were isolated from the seeds of T. yunnanensis and identified as 7-epi-10-deacetyltaxol (1), 2-deacetoxytaxuspine C (2), 9α-hydroxy-2α, 7α, 10β-triacetoxy-5α-cinnamoyloxy-3, 11-cyclotaxa-4(20)-en-13-one (3), 2α-acetoxy-5α-cinnamoyloxy-9α, 10β-dihydroxy-taxa-4 (20), 11-diene-13-one (4), dantaxusin C (5), taxezopidine H (6), 9-deacetyltaxinine A (7), 5α-decinnamoyltaxagifine (8), Taxumairol B (9), 2α, 5α, 13α-trihydroxy-7β, 9α, 10β-triacetoxy-taxa-4(20), 11-diene (10), 7, 9, 10, 13-tetra-O-deacetylabeobaccatin VI (11), and taxacustin (12).
CONCLUSIONS:
Compounds 2, 3, and 7-12 are isolated from T. yunnanensis for the first time.
