Stigmasterol glucoside
Stigmasterol glucoside, a constituent of Adenanthera pavonina seed and leaf, may be a plant anticancer agent.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Planta Medica,1985(6):544-545
Plant anticancer agents. XXXVI. Schottenol glucoside from Baccharis coridifolia and Ipomopsis aggregata.[Pubmed:
4095201]
Plant anticancer agents. XXXVI. Schottenol glucoside from Baccharis coridifolia and Ipomopsis aggregata.
Biol Pharm Bull . 2018;41(8):1307-1310.
Screening of Euphorbiaceae Plant Extracts for Anti-5α-reductase[Pubmed:
30068884]
Abstract
In our research program to find novel agents for alopecia from natural plant resources, we screened Euphorbiaceae plant extracts using an anti-5α-reductase assay. Among the samples tested, the extract of Phyllanthus urinaria showed the most potent activity with 24.3 and 64.6% inhibition at 50 and 200 μg/mL against the enzyme, respectively. The extract also suppressed the androgen activity of dihydrotestosterone in LNCaP cell line. These results show that the extract of P. urinaria may be a multi-potent agent for androgen-derived alopecia. We tested for activity on a hair regrowth model using mice. The extract of P. urinaria showed hair regrowth activity at 5 mg/mouse/d administration. Furthermore, the active principle for anti-5α-reductase activity was determined as Stigmasterol glucoside from activity-guided fractionation and the IC50 was 27.2 μM. These results suggest that extract of P. urinaria may be a promising candidate anti-alopecia agent.
Keywords: 5α-reductase; Euphorbiaceae; Phyllanthus urinaria; androgen receptor; Stigmasterol glucoside.
Phytochemistry. 2008 Feb;69(4):1000-4.
Withanolides from Withania somnifera roots.[Pubmed:
18061221]
Two new and seven known withanolides along with beta-sitosterol, stigmasterol, beta-sitosterol glucoside, Stigmasterol glucoside, alpha+beta glucose were isolated from the roots of Withania somnifera.
METHODS AND RESULTS:
Among the known compounds, Viscosa lactone B, stigmasterol, Stigmasterol glucoside and alpha+beta glucose are being reported from the roots of W. somnifera for the first time. One of the new compounds contained the rare 16beta-acetoxy-17(20)-ene the other contained unusual 6alpha-hydroxy-5,7alpha-epoxy functional groups in the withasteroid skeleton.
CONCLUSIONS:
The structures were elucidated by spectroscopic methods and chemical transformations.
Planta Med.,1973 Mar;23(2):145-8.
Stigmasterol glucoside a constituent of Adenanthera pavonina seed and leaf.[Pubmed:
4705793 ]
Stigmasterol glucoside, dulcitol, a polysaccharide and free stigmasterol from the seeds and octacosanol, dulcitol, glucosides of β–sitosterol and stigmasterol from the leaves have been isolated and characterised. Stigmasterol, Stigmasterol–β–D–glukosid, Dulcitol und ein Polysaccharid aus den Samen und Glukoside von β–Sitosterol und Stigmasterol, Octakosanol und Dulcitol aus den Bl01ttern der Adenanthera pavonina Linn. wurden isoliert und charakterisiert.
