Spectabiline
Spectabiline shows tumor-inhibitory properties against one or more test tumors. Spectabiline, monocrotaline, sarracine, lasiocarpine, 7-angelylheliotridine, heliotrine and senecionine have similar antagonistic potencies against responses to both acetylcholine and histamine.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Br J Pharmacol. 1971 Apr;41(4):683-90.
Pyrrolizidine alkaloids: actions on muscarinic receptors in the guinea-pig ileum.[Pubmed:
5579465]
METHODS AND RESULTS:
1. Eleven pyrrolizidine alkaloids have been tested on the isolated guinea-pig ileum preparation.2. Platyphylline, supinine, heleurine and cynaustraline were more potent in antagonizing responses to acetylcholine and carbachol than responses to histamine. Their anticholinergic activity appeared to involve a competitive mechanism.3. Lasiocarpine, monocrotaline, Spectabiline, sarracine, 7-angelylheliotridine, heliotrine and senecionine had similar antagonistic potencies against responses to both acetylcholine and histamine.
CONCLUSIONS:
4. The alkaloids had no appreciable activity as antagonists of acetylcholine in the isolated toad rectus abdominis preparation.5.
These results are discussed with respect to interactions of the alkaloids at receptor sites involved in anticholinergic activity at the muscarinic receptor.
J Pharm Sci. 1968 Jul;57(7):1112-7.
Tumor-inhibitory activity of pyrrolizidine alkaloids[Reference:
WebLink]
METHODS AND RESULTS:
Eighteen pyrrolizidine alkaloids and several derivatives have been examined for tumor-inhibitory properties. Of these, 10 compounds show significant activity against one or more test tumors. Heliotrine, lasiocarpine, monocrotaline, Spectabiline, and senecionine are highly active against the Walker 256 (intramuscular) system.
CONCLUSIONS:
The activity pattern is consistent with the tumor-inhibitory action being associated with the allylic ester function which imparts alkylating ability and is also responsible for hepatotoxicity.
