Soyasaponins(Aa, Ab, Af, Ba, Bb, and Bb') together with their derivatives may represent viable candidates for effective vaccine adjuvants due to their higher and lower or non-haemolytic effects.Soyasaponins Ab and Bb prevent scopolamine-induced memory impairment in mice without the inhibition of acetylcholinesterase.
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Soyasaponins Ab and Bb prevent scopolamine-induced memory impairment in mice without the inhibition of acetylcholinesterase.[Pubmed: 24450802
Soy (Glycine max, family Leguminosae), which contains isoflavones and saponins as main constituents, is known to exhibit memory-enhancing effects.
METHODS AND RESULTS:
Therefore, to investigate the role of soyasaponins in memory impairments, we isolated soyasaponin Ab (SA) and soyasaponin Bb (SB) from soybean and measured their protective effects against scopolamine-induced memory impairment in mice. SA and SB significantly prevented scopolamine-induced memory impairment in passive avoidance and Y-maze tasks. Compared to SA, SB rescued memory impairment more potently. Treatment with SB (10 mg/kg, p.o.) protected memory impairment in passive avoidance and Y-maze tasks to 97% (F = 68.10, P < 0.05) and 78% (F = 35.57, P < 0.05) of untreated normal control level, respectively. SA and SB (10 mg/kg) also rescued scopolamine-induced memory impairment in Morris water maze task (F = 14.51, P < 0.05). In addition, soyasaponins preserved brain-derived neurotrophic factor (BNDF) expression (F = 33.69, P < 0.05) and cAMP response element-binding (CREB) protein phosphorylation (F = 91.62, P < 0.05) in the hippocampus of scopolamine-treated mice. However, SA and SB did not inhibit acetylcholinesterase in vitro and ex vivo.
On the basis of these findings, we suggest that soybean, particularly soyasaponins, may protect memory impairment by increasing BDNF expression and CREB phosphorylation.
《Journal of Medical Science Yanbian University》 2002-04
Determination of soyasaponin Ba and Bb in Soybean Hypocotyl by high performance liquid chromatography[Reference: WebLink
To establish a method for determination of Soyasaponin Ba and Bb.
METHODS AND RESULTS:
Soyasaponin Ba and Bb were detected by a reversed-phase liquid chromatographic method. The method was proved to be linear in the range of 2 24～11 20μg and 2 35～11 80μg, and the intra-day coefficients of variation of assay for Soyasaponin Ba and Bb were 3 15% and 3 98%, respectively.
The method is accurate and reproducible, suitable for determination of Soyasaponin Ba and Bb.