Rehmapicroside

Acta Pharmaceutica Sinica B,2013,3(5): 333–336.

A new megastigmane from fresh roots of Rehmannia glutinosa[Reference: WebLink]

METHODS AND RESULTS:
A new megastigmane, rehmamegastigmane (1), together with eighteen known compounds lariciresinol (2), lariciresinol-4′-O-β-d-glucopyranoside (3), hierochin D (4), yemuoside YM1 (5), darendoside B (6), decaffeoylacteoside (7), jionoside B1 (8), catalpol (9), ajugol (10), 6-O-vanilloylajugol (11), 6-O-E-feruloylajugol (12), Rehmapicroside (13), rehmapicrogenin (14), 3-methoxy-2,6,6-trimethylcyclohexane-1-enecarboxylic acid (15), vanillic acid (16), hydroferulic acid (17), threo-1-(4-hydroxy-3-methoxyphenyl)-1,2,3-propanetriol (18), p-hydroxyphenylethyl alcohol (19) was isolated from the fresh roots of Rehmannia glutinosa.
CONCLUSIONS:
Compounds 2–6 and 16–18 were isolated from this plant for the first time.

Nat Prod Res. 2015;29(1):59-63.

Two new ionone glycosides from the roots of Rehmannia glutinosa Libosch.[Pubmed: 25232801]

METHODS AND RESULTS:
Two new ionone glycosides, named frehmaglutoside G (1) and frehmaglutoside H (2), together with six known compounds, Rehmapicroside (3), sec-hydroxyaeginetic acid (4), dihydroxy-β-ionone (5), trihydroxy-β-ionone (6), rehmaionoside A (7) and rehmaionoside C (8), were isolated from the 95% EtOH extract of the dried roots of Rehmannia glutinosa Libosch.
CONCLUSIONS:
Their structures were determined on the basis of extensive spectroscopic analyses, including HR-ESI-MS, UV, IR, 1D and 2D NMR ((1)H-(1)H COSY, HSQC, HMBC and NOESY) methods. The absolute configurations were confirmed via the circular dichroism spectra.