Rauvovertine A
Rauvovertine A shows cytotoxicity in vitro against human tumor cell lines.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Int Immunopharmacol.2021, 100:108073.
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ACS Synth Biol.2022, doi: 10.1021.
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Fitoterapia. 2015 Dec;107:44-48.
Hexacyclic monoterpenoid indole alkaloids from Rauvolfia verticillata.[Pubmed:
26474672 ]
METHODS AND RESULTS:
Five new hexacyclic monoterpenoid indole alkaloids, Rauvovertine A (1), 17-epi-Rauvovertine A (2), Rauvovertine B (3), 17-epi-Rauvovertine B (4), and rauvovertine C (5) together with 17 known analogues were isolated from the stems of Rauvolfia verticillata. Compounds 1/2 and 3/4 were obtained as C-17 epimeric mixtures due to rapid hemiacetal tautomerism in solution.
CONCLUSIONS:
The structures of 1-5 were established by spectroscopic analysis and with the aid of molecular modeling.
The new alkaloids were evaluated for their cytotoxicity in vitro against human tumor HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines.
