Peroxydehydrotumulosic acid

Peroxydehydrotumulosic acid
Product Name Peroxydehydrotumulosic acid
CAS No.: 943225-53-4
Catalog No.: CFN92836
Molecular Formula: C31H46O6
Molecular Weight: 514.7 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Source: The roots of Wolfiporia cocos (Schw.) Ryv.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
5alpha,8alpha-Peroxydehydrotumulosic acid exhibits inhibitory effects against the Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Journal of Medicinal Plant Research.2013 Nov 7
  • Oncotarget. 2017 Jun 28;
  • Plant J. 2017 May;
  • Front Pharmacol. 2016 Nov 30
  • J Ethnopharmacol.2017 Sep 14;
  • Mol Med Rep.2014 May;9(5):1653-9.
  • J Pharm Biomed Anal. 2016 Jun 25;129:50-59.
  • Neuropharmacology.2018 Mar 15;
  • Biochem Biophys Res Commun.2017 Jan 22;
  • The Korea Society of Pharmacognosy.2014
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    J Nat Prod. 2007 Jun;70(6):948-53. Epub 2007 May 9.
    Triterpene acids from Poria cocos and their anti-tumor-promoting effects.[Pubmed: 17488130 ]
    The structures of six new lanostane-type triterpene acids isolated from the epidermis of the sclerotia of Poria cocos were established to be 15alpha-hydroxydehydrotumulosic acid (5), 16alpha,25-dihydroxydehydroeburicoic acid (9), 5alpha,8alpha-Peroxydehydrotumulosic acid (10), 25-hydroxyporicoic acid H (11), 16-deoxyporicoic acid B (12), and poricoic acid CM (16) on the basis of spectroscopic methods.
    METHODS AND RESULTS:
    On evaluation of these six and 11 other known triterpene acids isolated from the sclerotium, 1-4, 6-8, 13-15, and 17, against the Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells, all of the compounds except for 1, 3, 4, and 8 exhibited inhibitory effects with IC50 values of 195-340 mol ratio/32 pmol TPA. Compound 12 and poricoic acid C (13) exhibited inhibitory effects on skin tumor promotion in an in vivo two-stage carcinogenesis test using 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter.
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