Norwogonin

Norwogonin
Product Name Norwogonin
CAS No.: 4443-09-8
Catalog No.: CFN92218
Molecular Formula: C15H10O5
Molecular Weight: 270.2 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Yellow powder
Targets: VHR
Source: The roots of Scutellaria baicalensis Georgi
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $388/10mg
Norwogonin(IC 50 = 1.1 microM) shows potent inhibitory activity toward VHR.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Sci Rep.2018, 8:15059
  • Mol Pharm.2017, 14(9):3164-3177
  • Pharmacognosy Magazine2018, 14(56):418-424
  • Chemistry of Vegetable Raw Materials2019, 3:119-127
  • Nat Prod Commun.2014, 9(5):679-82
  • Toxicol Res.2019, 35(4):371-387
  • Lab Chip.2018, 18(6):971-978
  • Int J Mol Sci.2018, 19(2)
  • The Japan Society for Analy. Chem.2017, 66(8):613-617
  • Korean Journal of Pharmacognosy.2015, 46(4):352-364
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    Inhibition of VHR dual-specificity protein tyrosine phosphatase activity by flavonoids isolated from Scutellaria baicalensis: structure-activity relationships.[Pubmed: 12494330]
    Three flavonoids: Norwogonin, dihydroNorwogonin and baicalein, were isolated from the roots of Scutellaria baicalensis, as potential inhibitors of VHR dual-specificity protein tyrosine phosphatase (DS-PTPase).
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    CONCLUSIONS:
    From comparisons to the inhibitory activities of other similar flavonoids, it could be suggested that the presence of a hydroxy group in the B ring of flavonoids interferes with the inhibitory activity toward VHR DS-PTPase.
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