Norsanguinarine
Norsanguinarine has antifungal activity, it exhibits 100 % inhibition of A. brassicicola and C. maculans at 1000 ppm whereas. It shows significant cytotoxic activities (ED (50) values < 4 microg/ml) against P-388, KB16, A549, and HT-29 cell lines.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Phytomedicine.2024, 125:155350.
Front Pharmacol.2021, 12:652860.
Int. J. Mol. Sci.2022, 23(14),7699;
Molecules.2022, 27(21):7514.
Int J Med Sci.2020, 17(5):626-631
J.Pharm. & Biome. Anal.2023, 2: 100018.
Front Pharmacol.2018, 9:756
Int J Mol Sci.2021, 22(16):8641.
Molecules.2022, 27(2):451.
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Folia Microbiol., 2009, 54(3):204-6.
Antifungal activity of the alkaloids from Eschscholtzia californica[Pubmed:
19649736 ]
METHODS AND RESULTS:
The isoquinoline alkaloids hunnemanine and Norsanguinarine have been isolated from methanolic extract of the whole plant of Eschscholzia californica. These two alkaloids were checked for their antifungal activity against phytopathogenic fungi Alternaria melongenae, A. brassicola, A. brassicae, Curvularia lunata, C. maculans, Helminthosporium pennisetti, H. oryzae, H. turcicum, Fusarium undum and F. lini.
CONCLUSIONS:
Hunnemanine exhibited 100 % inhibition of spore germination of A. brassicae, H. pennisetti and F. lini at 1000 ppm whereas Norsanguinarine exhibited 100 % inhibition of A. brassicicola and C. maculans at this concentration.
Journal of Molecular Structure.2004 Feb 3;689(1–2):115–120.
Theoretical and experimental NMR chemical shifts of norsanguinarine and norchelerythrine.[Reference:
WebLink]
METHODS AND RESULTS:
Norchelerythrine and Norsanguinarine, tertiary benzo[c]phenanthridine alkaloids, were examined by gradient-selected 2D NMR spectroscopy and the later also by extensive theoretical calculations.
