6-Acetonyldihydrochelerythrine

Planta Med. 2003 Feb;69(2):148-52.

Two new protopines argemexicaines A and B and the anti-HIV alkaloid 6-acetonyldihydrochelerythrine from formosan Argemone mexicana.[Pubmed: 12624820]

METHODS AND RESULTS:
Antioxidative activity-guided fractionation together with chemical analysis led to the isolation of three benzophenanthridine alkaloids from methanol extract of the bark of Bocconia arborea. Identification was based on spectroscopic methods. The isolated alkaloids 6-Acetonyldihydrochelerythrine, chelerythrine and dihydrochelerythrine were tested for antioxidative activity on thiocyanate assays, free radical scavenging activity, β β β β β-carotene bleaching method, and deoxyribose assay.
CONCLUSIONS:
All alkaloids exhibited significant antioxidant activities in linoleic acid and β β β β β-carotene. Although afforded protection against the damage of deoxyribose, liposome peroxidation and microsomial lipid from peroxidation, also exhibited scavenging effects on the 1,1-diphenyl-2-picrylhydrazyl radicals.

Ars Pharmaceutica,2003,44(1):5-21.

Actividad antioxidante de los alcaloides de Bocconia arborea. Estudio sobre seis métodos de análisis Antioxidant activity of alkaloids from Bocconia arborea. A study on six testing methods[Reference: WebLink]

METHODS AND RESULTS:
Antioxidative activity-guided fractionation together with chemical analysis led to the isolation of three benzophenanthridine alkaloids from methanol extract of the bark of Bocconia arborea. Identification was based on spectroscopic methods. The isolated alkaloids 6-Acetonyldihydrochelerythrine, chelerythrine and dihydrochelerythrine were tested for antioxidative activity on thiocyanate assays, free radical scavenging activity, β β β β β-carotene bleaching method, and deoxyribose assay.
CONCLUSIONS:
All alkaloids exhibited significant antioxidant activities in linoleic acid and β β β β β-carotene. Although afforded protection against the damage of deoxyribose, liposome peroxidation and microsomial lipid from peroxidation, also exhibited scavenging effects on the 1,1-diphenyl-2-picrylhydrazyl radicals.

J Nat Prod. 2014 Jul 28.

6-Acetonyldihydrochelerythrine Is a Potent Inducer of Apoptosis in HCT116 and SW620 Colon Cancer Cells.[Pubmed: 25066282]

Three flavones [Desmethoxycentaureidin (10), eupafolin (11), and 6-hydroxyluteolin (12)] from the latter.
METHODS AND RESULTS:
Antiproliferative activity of the isolated compounds against murine melanoma (B16F10), human gastric adenocarcinoma (MK-1), and human uterine carcinoma (HeLa) cells was estimated. (+)-Anymol (3), acteoside (4), isoacteoside (5), arenarioside (8), eupafolin (11), and 6-hydroxyluteolin (12) had GI50 values of 10-16 microM against B16F10 cell.
CONCLUSIONS:
Desmethoxycentaureidin (10) and eupafolin (11) showed high inhibitory activity against HeLa cell growth (GI50 9 microM, and 6 microM, respectively).