Nimbin
Nimbin is an anti-pyretic, can be used to treat arthritis, hypoglycaemia, peptic ulcers, anti-secretory activity, and it can also be used as an antibiotic. Nimbin requires to elicit a 50% inhibition of this steroid hydroxylase activity in the three insect species examined ranged from approximately 2 x 10(-5) to 1 x 10(-3). Nimbin also shows anti-feedant activity and toxicity against larvae of three species of Lepidoptera, Spodoptera littoralis (Boisd), Spodoptera frugiperda (FE Smith) and Helicoverpa armigera (Hübner) and nymphs of the locusts Schistocerca gregaria (Forskål) and Locusta migratoria (L).
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Pest Manag Sci. 2004 May;60(5):459-64.
Comparison of anti-feedant and insecticidal activity of nimbin and salannin photo-oxidation products with neem (Azadirachta indica) limonoids.[Pubmed:
15154512]
Photo-oxidation of the neem limonoids Nimbin and salannin with UV light in the presence of oxygen gives two isomeric lactone products per limonoid, Nimbinolide and isoNimbinolide, and salanninolide and isosalanninolide, respectively.
METHODS AND RESULTS:
When compared in insect tests with the important limonoids of neem seeds, azadirachtin, Nimbin and salannin, isoNimbinolide and isosalanninolide show activity greater than that of Nimbin or salannin and in some respects show activity approaching that of azadirachtin.
The photo-oxidation products were tested for anti-feedant activity and toxicity against larvae of three species of Lepidoptera, Spodoptera littoralis (Boisd), Spodoptera frugiperda (FE Smith) and Helicoverpa armigera (Hübner) and nymphs of the locusts Schistocerca gregaria (Forskål) and Locusta migratoria (L).
J. Food Eng., 2001, 47(4): 289-93.
Supercritical CO2 extraction of nimbin from neem seeds - an experimental study[Reference:
WebLink]
Nimbin is one of the many substances found in neem seeds and is reported to have several medicinal properties and uses. For example, it is an anti-pyretic, can be used to treat arthritis, hypoglycaemia, peptic ulcers, anti-secretory activity, and it can also be used as an antibiotic.
METHODS AND RESULTS:
In this paper, we present the results of a preliminary experimental study to extract Nimbin from neem seeds using CO2 supercritical fluid extraction (SFE). The operating pressure in the extraction was varied from 10 to 26 MPa, the temperature was varied from 308 to 333 K and the flow rate was varied from 0.24 to 1.24 ml/min. An optimum extraction rate was observed at a pressure of 23 MPa when operating at 308 K. Best extraction conditions occurred at 23 MPa, 308 K and a flow rate of 1.24 ml/min for a 2 g sample of neem.
METHODS AND RESULTS:
The measured extraction rate was found to be about 0.18 mg of Nimbin/g neem seed per hour of operation which is equivalent to about 0.35 kg Nimbin extracted per kg Nimbin present in neem seeds.
J Alzheimers Dis Rep . 2019 Jun 14;3(1):169-178.
Neem Derivatives Inhibits Tau Aggregation[Pubmed:
31259310]
Abstract
Tau is a phosphoprotein with natively unfolded conformation that functions to stabilize microtubules in axons. Alzheimer's disease pathology triggers several modifications in tau, which causes it to lose its affinity towards microtubule, thus, leading to microtubule disassembly and loss of axonal integrity. This elicit accumulation of tau as paired helical filaments is followed by stable neurofibrillary tangles formation. A large number of small molecules have been isolated from Azadirachta indica with varied medicinal applications. The intermediate and final limonoids, Nimbin and salannin respectively, isolated from Azadirachta indica, were screened against tau aggregation. ThS and ANS fluorescence assay showed the role of intermediate and final limonoids in preventing heparin induced cross-β sheet formation and also decreased hydrophobicity, which are characteristic nature of tau aggregation. Transmission electron microscopy studies revealed that limonoids restricted the aggregation of tau to fibrils; in turn, limonoids led to the formation of short and fragile aggregates. Both the limonoids were non-toxic to HEK293T cells thus, substantiating limonoids as a potential lead in overcoming Alzheimer's disease.
Keywords: Aggregation; Alzheimer’s disease; limonoids; natural products; tau.
Arch Insect Biochem Physiol. 1997;35(1-2):199-209.
Effects of the neem tree compounds azadirachtin, salannin, nimbin, and 6-desacetylnimbin on ecdysone 20-monooxygenase activity.[Pubmed:
9131784]
The effects of azadirachtin, salannin, Nimbin, and 6-desacetylNimbin on ecdysone 20-monooxygenase (E-20-M) activity were examined in three insect species.
METHODS AND RESULTS:
Homogenates of wandering stage third instar larvae of Drosophila melanogaster, or abdomens from adult female Aedes aegypti, or fat body or midgut from fifth instar larvae of Manduca sexta were incubated with radiolabeled ecdysone and increasing concentrations (from 1 x 10(-8) to 1 x 10(-3) M) of the four compounds isolated from seed kernels of the neem tree, Azadirachta indica. All four neem tree compounds were found to inhibit, in a dose-dependent fashion, the E-20-M activity in three insect species.
CONCLUSIONS:
The concentration of these compounds required to elicit a 50% inhibition of this steroid hydroxylase activity in the three insect species examined ranged from approximately 2 x 10(-5) to 1 x 10(-3).
