Nephthenol
Nephthenol shows antiproliferative activity against the cell lines HUVEC and K-562 and for cytotoxicity against the cell line HeLa.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Bioorg Chem.2024, 150:107558.
Research Square2020, doi: 10.21203.
Sci Rep. 2017, 17332(7)
Mol Pharm.2018, 15(8):3285-3296
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Chem Biodivers. 2010 Aug;7(8):2007-15.
Terpenes from the soft corals Litophyton arboreum and Sarcophyton ehrenbergi.[Pubmed:
20730963 ]
METHODS AND RESULTS:
The new cembrane diterpene (3E,11E)-cembra-3,8(19),11,15-tetraene-7alpha-ol (1), Nephthenol (2), and all-trans-peridinin (3) have been isolated from the soft coral Litophyton arboreum. The tetraterpene 3, (+)-7,8-epoxy-7,8-dihydrocembrene C (4), emblide (5), sarcophytoxide (6), sarcoglaucol-16-one (7), guajacophine (8), and 1,4-peroxymuurol-5-ene (9) have been obtained from the soft coral Sarcophyton ehrenbergi. The compounds were characterized primarily by NMR spectroscopy.
CONCLUSIONS:
Some of the terpenes were tested for their antiproliferative activity against the cell lines HUVEC and K-562 and for cytotoxicity against the cell line HeLa, and they showed moderate activities.
Nat Prod Res. 2018 May 17:1-7.
New cembrane-type diterpenoids from Bornean soft coral Nephthea sp. with antifungal activity against Lagenidium thermophilum.[Pubmed:
29772929 ]
METHODS AND RESULTS:
Three new cembrane diterpenes, nephthecrassocolides A-B (1-2) and 6-acetoxy Nephthenol acetate (3) along with three known compounds, 6-acetoxy-7,8-epoxy Nephthenol acetate (4), epoxy Nephthenol acetate (5) and Nephthenol (6) were isolated from one population of Nephthea sp.
CONCLUSIONS:
Their structures were elucidated based on spectroscopic data analysis and the antifungal activities of compounds 1-6 were evaluated.
