Moracin M
Moracin M is a phytoalexin. Moracin M inhibits PDE4D2, PDE4B2, PDE5A1, and PDE9A2 with the IC(50) values of 2.9, 4.5, >40, and >100 μM, respectively.
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Food Chem.2019, 274:345-350
HIV Med.2021, 22(8):690-704.
SCOPUS.2020, 836-847.
Cell Physiol Biochem.2019, 52(6):1255-1266
TCI CO.2019, US20190151281A1
Sci Rep.2015, 5:13194
Plant Direct.2021, 5(12):e372.
Int J Mol Sci.2022, 23(23):14826.
Exp Biol Med (Maywood).2019, 244(18):1665-1679
Pharm Biol.2017, 55(1):360-366
Related and Featured Products
Bioorg Med Chem Lett . 2012 May 1;22(9):3261-4.
Moracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor[Pubmed:
22483586]
Abstract
Phosphodiesterase-4 (PDE4) has been identified to be a promising target for treatment of asthma. Moracin M extracted from Chinese herbal drug 'Sang-Bai-Pi' (Morus alba L.) was studied for the inhibitory affinity towards PDE4. It inhibited PDE4D2, PDE4B2, PDE5A1, and PDE9A2 with the IC(50) values of 2.9, 4.5, >40, and >100 μM, respectively. Our molecular docking and 8ns molecular dynamics (MD) simulations demonstrated that Moracin M forms three hydrogen bonds with Gln369, Asn321, and Asp318 in the active site and stacks against Phe372. In addition, comparative kinetics analysis of its analog moracin C was carried out to qualitatively validate their inhibitory potency as predicted by the binding free energy calculations after MD simulations.
Bioorg Med Chem Lett. 2012 May 1;22(9):3261-4.
Moracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor.[Pubmed:
22483586]
Phosphodiesterase-4 (PDE4) has been identified to be a promising target for treatment of asthma.
METHODS AND RESULTS:
Moracin M extracted from Chinese herbal drug 'Sang-Bai-Pi' (Morus alba L.) was studied for the inhibitory affinity towards PDE4. It inhibited PDE4D2, PDE4B2, PDE5A1, and PDE9A2 with the IC(50) values of 2.9, 4.5, >40, and >100 μM, respectively.
CONCLUSIONS:
Our molecular docking and 8ns molecular dynamics (MD) simulations demonstrated that Moracin M forms three hydrogen bonds with Gln369, Asn321, and Asp318 in the active site and stacks against Phe372. In addition, comparative kinetics analysis of its analog moracin C was carried out to qualitatively validate their inhibitory potency as predicted by the binding free energy calculations after MD simulations.
(1,5E,11E)-tridecatriene-7,9-diyne-3,4-diacetate
Catalog No: CFN95161
CAS No: 201012-14-8
Price: $318/10mg
ent-16beta,17-dihydroxy-9(11)-kauren-19-oic acid
Catalog No: CFN95172
CAS No: 55483-24-4
Price: $318/10mg
6'-Feruloylnodakenin
Catalog No: CFN95202
CAS No: 131623-14-8
Price: $318/10mg
Perlolyrine
Catalog No: CFN95291
CAS No: 29700-20-7
Price: $413/5mg
Arvenin III
Catalog No: CFN95327
CAS No: 65597-45-7
Price: $318/5mg
4'-Hydroxy-3',5,5',6,7,8-hexamethoxyflavone
Catalog No: CFN95407
CAS No: 85644-03-7
Price: $318/5mg
Oleracein E
Catalog No: CFN95441
CAS No: 1021950-79-7
Price: $318/5mg
12-Acetoxy ganoderic acid D
Catalog No: CFN95535
CAS No: N/A
Price: $318/5mg
New compound 22
Catalog No: CFN95570
CAS No: N/A
Price: $413/5mg
Mahuannin E
Catalog No: CFN95585
CAS No: 1173887-70-1
Price: $318/5mg
