Mayumbine
Mayumbine (IC50 = 76 ± 3.5 nM) potently inhibit the in vitro binding of 3H-diazepam to the benzodiazepine sites within the rat GABAA receptor complex.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Natural Product Letters.1997;11(1):73-76.
The Heteroyohimbine Mayumbine Binds with High Affinity to Rat Brain Benzodiazepine Receptors in vitro.[Reference:
WebLink]
METHODS AND RESULTS:
Mayumbine, a naturally occurring heteroyohimbine, was isolated from Rauwolfia vomitoria extracts and shown to potently (IC50 = 76 ± 3.5 nM) inhibit the in vitro binding of 3H-diazepam to the benzodiazepine sites within the rat GABAA receptor complex.
