Lydicamycin
Lydicamycin is active against Gram-positive bacteria and a certain yeast.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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J Antibiot (Tokyo). 1991 Mar;44(3):282-7.
Lydicamycin, a new antibiotic of a novel skeletal type. I. Taxonomy, fermentation, isolation and biological activity.[Pubmed:
2026553]
METHODS AND RESULTS:
A novel antibiotic, designated Lydicamycin, was isolated from the fermentation broth of an actinomycete strain identified as Streptomyces lydicus. Lydicamycin was active against Gram-positive bacteria and a certain yeast, but inactive against Gram-negative bacteria.
J Antibiot (Tokyo). 2002 Oct;55(10):873-80.
TPU-0037-A, B, C and D, novel lydicamycin congeners with anti-MRSA activity from Streptomyces platensis TP-A0598.[Pubmed:
12523820]
METHODS AND RESULTS:
In screening for anti-MRSA antibiotics, novel Lydicamycin congeners, TPU-0037-A, B, C and D, were isolated from a culture broth of an actinomycete strain.
The producing strain, TP-A0598, was isolated from a seawater sample collected in Toyama Bay, Japan, and identified as Streptomyces platensis based on taxonomic characteristics. TPU-0037-A, B, C and D were purified by HP-20 resin, ODS column chromatographies and preparative HPLC, consecutively, and their structures were determined to be 30-demethylLydicamycin, 14,15-dehydro-8-deoxyLydicamycin, 30-demethyl-8-deoxyLydicamycin and 8-deoxyLydicamycin, respectively, by NMR and MS analyses.
CONCLUSIONS:
The new congeners showed antibiotic activity against gram-positive bacteria including MRSA with the MIC of 1.56 to approximately 12.5 microg/ml.
J Antibiot (Tokyo). 1991 Mar;44(3):288-92.
Lydicamycin, a new antibiotic of a novel skeletal type. II. Physico-chemical properties and structure elucidation.[Pubmed:
2026554 ]
METHODS AND RESULTS:
The structure of a new antibiotic designated Lydicamycin was elucidated as shown in Fig. 1 by NMR spectral analysis including a variety of 2D techniques. Lydicamycin possesses a novel skeleton containing tetramic acid and amidinopyrrolidine moieties.
