Lydicamycin

J Antibiot (Tokyo). 1991 Mar;44(3):282-7.

Lydicamycin, a new antibiotic of a novel skeletal type. I. Taxonomy, fermentation, isolation and biological activity.[Pubmed: 2026553]

METHODS AND RESULTS:
A novel antibiotic, designated Lydicamycin, was isolated from the fermentation broth of an actinomycete strain identified as Streptomyces lydicus. Lydicamycin was active against Gram-positive bacteria and a certain yeast, but inactive against Gram-negative bacteria.

J Antibiot (Tokyo). 2002 Oct;55(10):873-80.

TPU-0037-A, B, C and D, novel lydicamycin congeners with anti-MRSA activity from Streptomyces platensis TP-A0598.[Pubmed: 12523820]

METHODS AND RESULTS:
In screening for anti-MRSA antibiotics, novel Lydicamycin congeners, TPU-0037-A, B, C and D, were isolated from a culture broth of an actinomycete strain. The producing strain, TP-A0598, was isolated from a seawater sample collected in Toyama Bay, Japan, and identified as Streptomyces platensis based on taxonomic characteristics. TPU-0037-A, B, C and D were purified by HP-20 resin, ODS column chromatographies and preparative HPLC, consecutively, and their structures were determined to be 30-demethylLydicamycin, 14,15-dehydro-8-deoxyLydicamycin, 30-demethyl-8-deoxyLydicamycin and 8-deoxyLydicamycin, respectively, by NMR and MS analyses.
CONCLUSIONS:
The new congeners showed antibiotic activity against gram-positive bacteria including MRSA with the MIC of 1.56 to approximately 12.5 microg/ml.

J Antibiot (Tokyo). 1991 Mar;44(3):288-92.

Lydicamycin, a new antibiotic of a novel skeletal type. II. Physico-chemical properties and structure elucidation.[Pubmed: 2026554 ]

METHODS AND RESULTS:
The structure of a new antibiotic designated Lydicamycin was elucidated as shown in Fig. 1 by NMR spectral analysis including a variety of 2D techniques. Lydicamycin possesses a novel skeleton containing tetramic acid and amidinopyrrolidine moieties.