Levistilide A

Levistilide A
Product Name Levistilide A
CAS No.: 88182-33-6
Catalog No.: CFN99707
Molecular Formula: C24H28O4
Molecular Weight: 380.48 g/mol
Purity: >=98%
Type of Compound: Miscellaneous
Physical Desc.: Solid
Source: The roots of Angelica sinensis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $100/20mg
Traditional formula compatibility of Danggui-Shaoyao-San could significantly enhance levistilide A bioavailability compared with levistilide A alone and Rhizoma Chuanxiong.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • bioRxiv - Biochemistry2023, 541790.
  • J Pharm Biomed Anal.2016, 129:50-59
  • Front Microbiol.2019, 10:2806
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  • Nutr Res Pract2019, 13:e45
  • bioRxiv - Biochemistry2023, 548213.
  • JPC-Journal of Planar Chromatography 2017, 30(4)
  • J.Korean Society of Grassland&Forage Science2023, 43(3):138-147.
  • Antioxidants (Basel).2021, 10(10):1620.
  • US20170000760 A12016, 42740
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    Abstract Background/aims: Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. Levistolide A (LA), a natural compound isolated from the traditional Chinese herb Ligusticum chuanxiong Hort, is used for treating cancer. In this study, we investigated the anticancer effect of LA in HCT116 and its isogenic p53-/- colon cancer cells, as well as the underlying mechanisms. Methods: MTT assay was used to evaluate the effect of LA on the viability of cancer cells. Apoptosis and reactive oxygen species (ROS) production by the cells were determined by flow cytometry. Protein expression was detected by western blotting. Results: The results showed that LA inhibited viability and caused apoptosis of both wild-type and p53-/- HCT116 cells. LA was able to trigger production of ROS and endoplasmic reticulum (ER) stress. Inhibition of ROS using N-acetylcysteine abrogated LA-induced ER stress and apoptosis, as well as the reduction in cancer cell viability. Conclusion: Our results indicate that LA causes apoptosis of colon cancer cells via ROS-mediated ER stress pathway. It will be interesting to develop the natural compound for chemotherapy of cancers such as CRC. Keywords: Apoptosis; ER stress; Levistolide A; ROS.
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    CONCLUSIONS:
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