Kushenol N
Kushenol N may have anti-allergic activity, it demonstrates significant inhibition of the release of beta-hexosaminidase from cultured RBL-2H3 cells .
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Journal of Life Science2017, 233-240
Int Immunopharmacol.2023, 125:111175.
PLoS One.2017, 12(8):e0181191
Trop J Nat Prod Res, February2023, 7(2):2371-2381
Molecules2021, 26(1),230
J Cell Mol Med.2020, 24(21):12308-12317.
Sci Rep. 2017, 8207(7)
In Vivo.2022, 36(3):1136-1143.
Food Structure2023, 36:100324.
The Journal of Supercritical Fluids2021, 176:105305.
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Planta Med. 2008 Feb;74(2):168-70.
Anti-allergic prenylated flavonoids from the roots of Sophora flavescens.[Pubmed:
18219599 ]
METHODS AND RESULTS:
The bioassay-guided fractionation of the MeOH extract from the root of Sophora flavescens led to the isolation of eight known prenylated flavonoids ( 1 - 8) responsible for the IN VITRO anti-allergic activity.
CONCLUSIONS:
Among them, Kushenol N ( 3), sophoraflavanone G ( 6), and leachianone A ( 7) demonstrated significant inhibition of the release of beta-hexosaminidase from cultured RBL-2H3 cells with IC (50) values ranging from 15 to 30 muM.
