Isorhynchophyllic acid
Isorhynchophyllic acid can significantly inhibit the proliferation of human cancer cells(A549, HepG2 and A2780 cells) with IC50 values being 5.8, 12.8 and 11.8 umol/L, respectively.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Pharmaceutics.2023, 15(6):1771.
Journal of Phytopathology2021, 169,Issue11-12.
Nat Commun.2023, 14(1):4540.
Food Sci Biotechnol.2023, 32(9):1215-1223.
Anticancer Agents Med Chem.2023, 23(10):1204-1210.
Front Cell Infect Microbiol.2018, 8:292
Toxicol In Vitro.2023, 93:105667.
Molecules.2019, 24(16):E2985
Microorganisms.2021, 9(12):2514.
Anticancer Res.2018, 38(4):2127-2135
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Chin. J. Nat. Med.,2016 Mar;14(3):232-5.
Two new ortho benzoquinones from Uncaria rhynchophylla.[Pubmed:
27025371]
The present study was designed to determine the chemical constituents of the stems and hooks of Uncaria rhynchophylla.
METHODS AND RESULTS:
The chemical constituents were isolated and purified from CH2Cl2 fraction by chromatography. Their structures were elucidated by spectroscopic analyses. Their cytotoxicity was tested using MTT method. Two new ortho benzoquinones, 3-diethylamino-5-methoxy-1, 2-benzoquinone (1) and 3-ethylamino-5-methoxy-1, 2-benzoquinone (2), together with a known compound Isorhynchophyllic acid (3) were isolated from U. rhynchophylla. These compounds were evaluated for their cytotoxicity against cancer cells A549, HepG2 and A2780.
CONCLUSIONS:
Compounds 1 and 2 were new ortho benzoquinones and showed weak antiproliferative activities on A549, HepG2 and A2780 cells. Compound 3 significantly inhibited the proliferation of A549, HepG2 and A2780 cells with IC50 values being 5.8, 12.8 and 11.8 μmol·L(-1), respectively.
