Isorhyncophylline
Isorhyncophylline and rhyncophylline can directly inhibit the contractile responses induced by several agonists in small blood vessels of rat, they also can inhibit the hypertensive effect of angiotensin Ⅱ.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Acta Academiae Medicinae Zunyi, 1994 (1) :7-10.
Effects of rhyncophylline and isorhyncophylline on the contractile responses of rat isolated mesenteric arteries and tail artery[Reference:
WebLink]
METHODS AND RESULTS:
In rat isolated mesenteric arteries and tail artery, rhyncopylline (Rhy)and Isorhyncophylline(Isorhy)inhibited the increased infusion pressure induced by high K+ (80 mmol/L) and noradrenaline(NA)in a concentration-dependent manner. The potency of both drugs were similar in mesenteric arteries, but in tail artery,the effect of Rhy on high K+ induced infusion pressure increase was weaker than that of Isorhy, and there was a similar trend in the contractile response induced by NA. Both drugs also inhibited the hypertensive effect of angiotensin Ⅱ.
CONCLUSIONS:
The results suggest that in small blood vessels of rat,Rhy and lsorhy can directly inhibit the contractile responses induced by several agonists, but in some arteries, the effect of Rhy may be weaker than that of Isorhy.
Phytochemistry.1984;23(2):453–455.
Indole alkaloids from Hannoa klaineana roots.[Reference:
WebLink]
1-Methoxycanthin-6-one, rhyncophylline, Isorhyncophylline and four new alkaloids, ethyl-β-carboline-1-propionate, ethyl-β-carboline-2N-oxide-1-propionate, 1-ethyl-β-carboline and 1-ethyl-β-carboline-2N-oxide, were isolated from three different samples of Hannoa klaineana roots.
