Isodonal

Chin J Nat Med. 2012 Jan;10(1):43-7.

Chemical constituents of flowers and fruits of Rabdosia excisa.[Pubmed: 23302530]

To study the chemical constituents in the flowers and fruits of Rabdosia excisa.
METHODS AND RESULTS:
The compounds were isolated and purified by silica gel column chromatography and their structures were identified by spectroscopic methods. Sixteen compounds isolated from the flowers and fruits of this plant were identified as: stigm asterol (I), α-amyrin palmitate (II), ursolic acid (III), 2α, 3α, 19-trihydroxy-urs-12-en-28-oic acid (IV), 2α-hydroxyursolic acid (V), maslinic acid (VI), Isodonal (VII), maoyecrystal E (VIII), kamebakaurin (XI), macrocalyxin G (X), epinodosinol (XI), rabdosichuanin C (XII), kamebacetal A (XIII), oridonin (XIV), enmenol-glucoside (XV), and lasiononin (XVI).
CONCLUSIONS:
All the constituents were found in Rabdosia excisa for the first time, except constituents III, IX, XII and XIV.

Chemical & Pharmaceutical Bulletin,2003, 51(7):790-3.

Ent-kaurane diterpenoids from Isodon rubescens var. lushanensis.[Reference: WebLink]

METHODS AND RESULTS:
Four new ent-kaurane diterpenoids lushanrubescensins F—I (1—4), together with 11 known ones, lasiodonin (5), oridonin (6), ponicidin (7), isodonoiol (8), Isodonal (9), rabdosin B (10), rabdoternins A and B (11 and 12), enmenol (13), epinodosin (14), and inflexusin (15), were isolated from Isodon rubescens var. lushanensis, and the structures were elucidated by spectroscopic analysis. The inhibitory effect against the K562, Bcap37, BGC823, BIU87, CA, CNE, and Hela cell lines of compounds 3 and 5—10 were evaluated.