Trichorabdal A
Trichorabdal A shows a very strong in vitro antibacterial activity against Helicobacter pylori.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Zentralbl Bakteriol. 1997 Jun;286(1):63-7.
Antibacterial activity of trichorabdal A from Rabdosia trichocarpa against Helicobacter pylori.[Pubmed:
9241802]
Rabdosia trichocarpa is used in a popular home-made remedy for gastric and stomachic complaints in Japan.
METHODS AND RESULTS:
A diterpene, Trichorabdal A from R. trichocarpa, showed a very strong in vitro antibacterial activity against Helicobacter pylori. With regard to the antibacterial activity of the extract and constituents of R. trichocarpa against H. pylori, the effect of traditional use of this plant for the treatment of gastritis is probably due to the suppression of H. pylori since the extract of R. trichocarpa particularly inhibits the growth of H. pylori.
CONCLUSIONS:
It could be a promising native herb treatment for patients with gastric complaints including gastric ulcer caused by H. pylori.
J Am Chem Soc. 2013 Aug 14;135(32):11764-7.
A unified strategy to ent-kauranoid natural products: total syntheses of (-)-trichorabdal A and (-)-longikaurin E.[Pubmed:
23886049]
METHODS AND RESULTS:
The first total syntheses of (-)-Trichorabdal A and (-)-longikaurin E are reported. A unified synthetic strategy is employed that relies on a Pd-mediated oxidative cyclization of a silyl ketene acetal to generate an all-carbon quaternary center and build the bicyclo[3.2.1]octane framework.
CONCLUSIONS:
These studies, taken together with our previous synthesis of (-)-maoecrystal Z, demonstrate that three architecturally distinct ent-kauranoids can be prepared from a common spirolactone intermediate.
