Isoapetalic acid

Isoapetalic acid
Product Name Isoapetalic acid
CAS No.: 34366-34-2
Catalog No.: CFN98450
Molecular Formula: C22H28O6
Molecular Weight: 388.5 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Targets: Antifection | HIV
Source: The leaves of Calophyllum brasiliense
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Isoapetalic acid and apetalic acid exhibit cytotoxic activities towards both cancer cell lines(human breast cancer (MCF-7) and human lung carcinoma (A-549) cell lines) and both Gram-positive bacteria(two Gram-positive bacteria, S. aureus and B. subtilis and two Gram-negative bacteria, P. aeruginosa and E. coli.).
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Biol Pharm Bull. 2004 Sep;27(9):1471-5.
    HIV-1 inhibitory compounds from Calophyllum brasiliense leaves.[Pubmed: 15340243 ]

    METHODS AND RESULTS:
    The hexane, acetone and methanol extracts of Calophyllum brasiliense leaves were fractionated following a three bioassay guide: high HIV-1 RT inhibition, low cytotoxicity on MT2 cells and high inhibition of HIV-1 IIIb/LAV replication. This led to the isolation of three anti HIV-1 dipyranocoumarins: calanolides A and B and soulattrolide. In contrast, other isolated compounds such as apetalic acid, Isoapetalic acid, a structural isomer of Isoapetalic acid, friedelin, canophyllol and amentoflavone were devoid of HIV-1 RT inhibitory activity.
    CONCLUSIONS:
    Calanolide C was also obtained as a natural product and showed moderate inhibitory properties.
    Nat.Prod. 2016, 10(5):649-53.
    Cytotoxic and Antibacterial Activities of Constituents from Calophyllum ferrugineum Ridley[Reference: WebLink]

    METHODS AND RESULTS:
    This study evaluated the chemical composition of Calophyllum ferrugineum, cytotoxicity against human breast cancer (MCF-7) and human lung carcinoma (A-549) cell lines as well as antibacterial activities against two Gram-positive bacteria, S. aureus and B. subtilis and two Gram-negative bacteria, P. aeruginosa and E. coli. Phytochemical investigations of the bark extract yielded Isoapetalic acid (1), apetalic acid (2), 6-hydroxy-2-methoxyxanthone (3) and ent-epicatechin (4). Meanwhile, betulinic acid (5), protocatechuic acid (6) and amentoflavone (7) were isolated from the leave extract. Isoapetalic acid (1) and apetalic acid (2) exhibited cytotoxic activities towards both cancer cell lines and both Gram-positive bacteria. Compounds (3-7) were inactive or showed moderate activities towards cytotoxic and antibacterial tests.
    CONCLUSIONS:
    This study presents the first report on the phytochemicals investigation from C. ferrugineum and all compounds are reported for the first time from this source.
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