Icariside I
Icariside I is a metabolite product of Icariin.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Processes 2021, 9(5),894.
J. of The Korean Society of Food Culture2017, 144-149
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Phytomedicine.2024, 128:155527.
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GxABT2022, 2268.2:15515.
Nanotechnology.2024, ad470d.
Int J Biol Macromol.2020, 169:342-351
Eur Rev Med Pharmacol Sci.2020, 24(9):5127-5139.
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J Cell Physiol. 2013 Mar;228(3):513-21.
Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodeling.[Pubmed:
22777826]
METHODS AND RESULTS:
Icariin, a prenylated flavonol glycoside isolated from Epimedium herb, stimulates osteogenic differentiation of BMSCs and inhibits bone resorption activity of osteoclasts. Icariin, whose metabolites include Icariside I, Icariside II, icaritin, and desmethylicaritin, has no estrogenic activity. However, icariin is more potent than genistein in promoting osteogenic differentiation and maturation of osteoblasts. The existence of a prenyl group on C-8 of icariin molecular structure has been suggested to be the reason why icariin is more potent than genistein in osteogenic activity.
CONCLUSIONS:
Thus, the prenylflavonoids may represent a class of flavonoids with a higher osteogenic activity.
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